Format

Send to:

Choose Destination
    • Showing Current items.

    Gata4 GATA binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54254, updated on 2-Oct-2018

    Summary

    Official Symbol
    Gata4provided by RGD
    Official Full Name
    GATA binding protein 4provided by RGD
    Primary source
    RGD:2665
    See related
    Ensembl:ENSRNOG00000010708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    plays a role in regulation of cardiac-myocyte specific gene expression; interacts with dHAND (HAND2) to activate transcription of several cardiac-specific genes [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 136.0), Testes (RPKM 66.9) and 1 other tissue See more
    Orthologs

    Genomic context

    See Gata4 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46386703..46458679, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (50151497..50197708, complement)

    Chromosome 15 - NC_005114.4Genomic Context describing neighboring genes Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene nei-like DNA glycosylase 2 Neighboring gene uncharacterized LOC102548615 Neighboring gene BLK proto-oncogene, Src family tyrosine kinase Neighboring gene family with sequence similarity 167, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    NFAT protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    co-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Sertoli cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    aortic valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum primum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrial septum secundum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    atrial septum secundum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular canal development ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cardiac muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac right ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
     
    cell growth involved in cardiac muscle cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to gonadotropin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic heart tube anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic heart tube development ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endocardial cushion development IEA
    Inferred from Electronic Annotation
    more info
     
    endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    endoderm formation ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    intestinal epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    lung lobe formation ISO
    Inferred from Sequence Orthology
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of connective tissue replacement ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of oxidative stress-induced cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardioblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction involved in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    transdifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor GATA-4
    Names
    DNA-binding protein GATA-GT2
    GATA-binding factor 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144730.1NP_653331.1  transcription factor GATA-4

      See identical proteins and their annotated locations for NP_653331.1

      Status: PROVISIONAL

      Source sequence(s)
      L22761
      UniProtKB/Swiss-Prot
      P46152
      Related
      ENSRNOP00000014320.3, ENSRNOT00000014320.5
      Conserved Domains (3) summary
      smart00401
      Location:267314
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:269320
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005114.4 Reference Rnor_6.0 Primary Assembly

      Range
      46386703..46458679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599788.1XP_017455277.1  transcription factor GATA-4 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal
    2. XM_006252189.3XP_006252251.1  transcription factor GATA-4 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal
    3. XM_017599789.1XP_017455278.1  transcription factor GATA-4 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal

    Alternate Rn_Celera

    Genomic

    1. AC_000083.1 Alternate Rn_Celera

      Range
      37143928..37189874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center