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    ADAM22 ADAM metallopeptidase domain 22 [ Homo sapiens (human) ]

    Gene ID: 53616, updated on 17-Nov-2018

    Summary

    Official Symbol
    ADAM22provided by HGNC
    Official Full Name
    ADAM metallopeptidase domain 22provided by HGNC
    Primary source
    HGNC:HGNC:201
    See related
    Ensembl:ENSG00000008277 MIM:603709; Vega:OTTHUMG00000137417
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MDC2; EIEE61; ADAM 22
    Summary
    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
    Expression
    Biased expression in brain (RPKM 9.0), adrenal (RPKM 2.5) and 10 other tissues See more
    Orthologs

    Genomic context

    See ADAM22 in Genome Data Viewer
    Location:
    7q21.12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (87934143..88202889)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87563566..87832204)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 1 Neighboring gene RUN domain containing 3B Neighboring gene origin of replication in promoter of DBF4 Neighboring gene solute carrier family 25 member 40 Neighboring gene DBF4 zinc finger Neighboring gene uncharacterized LOC105375386 Neighboring gene uncharacterized LOC102723885 Neighboring gene sorcin Neighboring gene STEAP4 metalloreductase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Early infantile epileptic encephalopathy 61
    MedGen: CN244550 OMIM: 617933 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of serious blistering skin rash caused by drugs.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • LGI-ADAM interactions, organism-specific biosystem (from REACTOME)
      LGI-ADAM interactions, organism-specific biosystemSynapse formation and maturation require multiple interactions between presynaptic and postsynaptic neurons. These interactions are mediated by a diverse set of synaptogenic proteins (Kegel et al. 20...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC149832

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    integrin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    myelination in peripheral nervous system IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 22
    Names
    a disintegrin and metalloproteinase domain 22
    metalloproteinase-disintegrin ADAM22-3
    metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324417.1NP_001311346.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes isoform 6. The encoded isoform (6) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
    2. NM_001324418.1NP_001311347.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) encodes isoform 7. The encoded isoform (7) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
    3. NM_001324419.1NP_001311348.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes isoform 8. The encoded isoform (8) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
    4. NM_001324420.1NP_001311349.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) encodes isoform 9. The encoded isoform (9) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
    5. NM_001324421.1NP_001311350.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform 10. The encoded isoform (10) may undergo proteolytic processing.
      Source sequence(s)
      AC004992, AC005075, AC005164, DR000609, R41888
    6. NM_004194.4NP_004185.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 4 precursor

      See identical proteins and their annotated locations for NP_004185.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as beta, uses an alternate splice site in the 3' coding region and lacks two downstream exons, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (4) may undergo proteolytic processing.
      Source sequence(s)
      AB009671, DR000609
      Consensus CDS
      CCDS43610.1
      UniProtKB/Swiss-Prot
      Q9P0K1
      Related
      ENSP00000381260.4, OTTHUMP00000207298, ENST00000398201.8, OTTHUMT00000338541
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    7. NM_016351.5NP_057435.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 3 precursor

      See identical proteins and their annotated locations for NP_057435.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as alpha, lacks an in-frame exon compared to variant 1. The encoded isoform (3) is shorter than isoform 1. The encoded isoform (3) may undergo proteolytic processing.
      Source sequence(s)
      AC005075, AC005164, AK291010, DR000609, R41888
      Consensus CDS
      CCDS43609.1
      UniProtKB/TrEMBL
      Q08AL8
      Related
      ENSP00000381262.4, OTTHUMP00000174585, ENST00000398204.8, OTTHUMT00000268368
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    8. NM_021721.4NP_068367.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 5 precursor

      See identical proteins and their annotated locations for NP_068367.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region and lacks one coding and two non-coding exons, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus, compared to isoform 1. The encoded isoform (5) may undergo proteolytic processing.
      Source sequence(s)
      AB009671, AF155381, DR000609
      UniProtKB/Swiss-Prot
      Q9P0K1
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    9. NM_021722.5NP_068368.2  disintegrin and metalloproteinase domain-containing protein 22 isoform 2 precursor

      See identical proteins and their annotated locations for NP_068368.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as delta, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. The encoded isoform (2) may undergo proteolytic processing.
      Source sequence(s)
      AC005075, AF155381, DR000609, R41888
      Consensus CDS
      CCDS43608.1
      UniProtKB/Swiss-Prot
      Q9P0K1
      Related
      ENSP00000381267.3, OTTHUMP00000174587, ENST00000398209.7, OTTHUMT00000268371
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    10. NM_021723.4NP_068369.1  disintegrin and metalloproteinase domain-containing protein 22 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_068369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as epsilon, encodes isoform 1, which is proteolytically processed to generate the mature protein.
      Source sequence(s)
      AC005075, AF155382, DR000609, R41888
      Consensus CDS
      CCDS47637.1
      UniProtKB/Swiss-Prot
      Q9P0K1
      Related
      ENSP00000265727.7, OTTHUMP00000207170, ENST00000265727.11, OTTHUMT00000268370
      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

      Range
      87934143..88202889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516319.3XP_011514621.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X3

      Conserved Domains (5) summary
      smart00608
      Location:529670
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:238435
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:452526
      Disintegrin; Disintegrin
      pfam01421
      Location:238437
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:74186
      Pep_M12B_propep; Reprolysin family propeptide
    2. XM_017012331.2XP_016867820.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X12

    3. XM_017012338.2XP_016867827.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X20

    4. XM_017012341.2XP_016867830.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X23

    5. XM_017012330.2XP_016867819.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X10

    6. XM_017012329.2XP_016867818.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X9

    7. XM_017012334.2XP_016867823.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X16

    8. XM_017012335.2XP_016867824.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X17

    9. XM_017012339.2XP_016867828.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X21

    10. XM_017012337.2XP_016867826.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X19

    11. XM_011516318.2XP_011514620.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X2

      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    12. XM_011516322.2XP_011514624.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X7

      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    13. XM_017012332.2XP_016867821.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X13

    14. XM_017012333.2XP_016867822.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X15

    15. XM_011516323.2XP_011514625.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X11

      Conserved Domains (5) summary
      smart00608
      Location:530671
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:239436
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:453527
      Disintegrin; Disintegrin
      pfam01421
      Location:239438
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:75187
      Pep_M12B_propep; Reprolysin family propeptide
    16. XM_017012336.2XP_016867825.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X18

    17. XM_006716028.4XP_006716091.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X1

      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    18. XM_011516320.3XP_011514622.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X4

      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    19. XM_011516321.3XP_011514623.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X5

      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    20. XM_005250445.4XP_005250502.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X8

      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    21. XM_006716029.4XP_006716092.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X6

      Conserved Domains (5) summary
      smart00608
      Location:582723
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:291488
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:505579
      Disintegrin; Disintegrin
      pfam01421
      Location:291490
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:127239
      Pep_M12B_propep; Reprolysin family propeptide
    22. XM_011516324.2XP_011514626.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X14

      Conserved Domains (5) summary
      smart00608
      Location:456597
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:165362
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:379453
      Disintegrin; Disintegrin
      pfam01421
      Location:165364
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:8113
      Pep_M12B_propep; Reprolysin family propeptide
    23. XM_017012340.2XP_016867829.1  disintegrin and metalloproteinase domain-containing protein 22 isoform X22

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