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    PAX8 paired box 8 [ Bos taurus (cattle) ]

    Gene ID: 534661, updated on 27-Aug-2018

    Summary

    Official Symbol
    PAX8provided by VGNC
    Official Full Name
    paired box 8provided by VGNC
    Primary source
    VGNC:VGNC:32599
    See related
    BGD:BT13297; Ensembl:ENSBTAG00000019354
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See PAX8 in Genome Data Viewer
    Location:
    11q22.1-q22.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 11 NC_037338.1 (46916023..46981272, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 11 AC_000168.1 (46784713..46851496, complement)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112448782 Neighboring gene interleukin 1 receptor antagonist Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene uncharacterized LOC112448875 Neighboring gene uncharacterized LOC100335748 Neighboring gene uncharacterized LOC100847269

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • ID signaling pathway, organism-specific biosystem (from WikiPathways)
      ID signaling pathway, organism-specific biosystemThe Inhibitor of DNA binding (ID) proteins belong to the class V HLH family of transcription factors. Four ID proteins (ID 1-4)are known in humans. Unlike the basic HLH (bHLH) transcription factors, ...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
      Thyroid hormone synthesis, organism-specific biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
    • Thyroid hormone synthesis, conserved biosystem (from KEGG)
      Thyroid hormone synthesis, conserved biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    General gene information

    Markers

    Homology

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      46916023..46981272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005212816.4XP_005212873.1  paired box protein Pax-8 isoform X3

      See identical proteins and their annotated locations for XP_005212873.1

      Conserved Domains (2) summary
      smart00351
      Location:9134
      PAX; Paired Box domain
      pfam12403
      Location:345422
      Pax2_C; Paired-box protein 2 C terminal
    2. XM_005212820.4XP_005212877.1  paired box protein Pax-8 isoform X5

      See identical proteins and their annotated locations for XP_005212877.1

      Conserved Domains (2) summary
      smart00351
      Location:9133
      PAX; Paired Box domain
      pfam12403
      Location:277386
      Pax2_C; Paired-box protein 2 C terminal
    3. XM_005212819.4XP_005212876.1  paired box protein Pax-8 isoform X4

      See identical proteins and their annotated locations for XP_005212876.1

      Conserved Domains (2) summary
      smart00351
      Location:9134
      PAX; Paired Box domain
      pfam12403
      Location:278387
      Pax2_C; Paired-box protein 2 C terminal
    4. XM_005212815.4XP_005212872.1  paired box protein Pax-8 isoform X1

      See identical proteins and their annotated locations for XP_005212872.1

      Related
      ENSBTAP00000025783.5
      Conserved Domains (2) summary
      smart00351
      Location:9134
      PAX; Paired Box domain
      pfam12403
      Location:345456
      Pax2_C; Paired-box protein 2 C terminal
    5. XM_002691400.6XP_002691446.2  paired box protein Pax-8 isoform X2

      See identical proteins and their annotated locations for XP_002691446.2

      Conserved Domains (2) summary
      smart00351
      Location:9133
      PAX; Paired Box domain
      pfam12403
      Location:344455
      Pax2_C; Paired-box protein 2 C terminal
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