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    PLG plasminogen [ Homo sapiens (human) ]

    Gene ID: 5340, updated on 3-Oct-2018

    Summary

    Official Symbol
    PLGprovided by HGNC
    Official Full Name
    plasminogenprovided by HGNC
    Primary source
    HGNC:HGNC:9071
    See related
    Ensembl:ENSG00000122194 MIM:173350; Vega:OTTHUMG00000015957
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
    Expression
    Restricted expression toward liver (RPKM 588.1) See more
    Orthologs

    Genomic context

    See PLG in Genome Data Viewer
    Location:
    6q26
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (160702193..160754054)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161123225..161175086)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene lipoprotein(a) like 2, pseudogene Neighboring gene lipoprotein(a) Neighboring gene plasminogen-like protein B Neighboring gene uncharacterized LOC105378091 Neighboring gene uncharacterized LOC112267969

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Plasminogen deficiency, type I
    MedGen: C1968804 OMIM: 217090 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genetic variants in PLG, LPA and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.
    NHGRI GWA Catalog
    Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.
    NHGRI GWA Catalog
    Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp779M0222

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    apolipoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proteasome core complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein antigen binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
     
    serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    extracellular matrix disassembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix disassembly TAS
    Traceable Author Statement
    more info
     
    fibrinolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibrinolysis TAS
    Traceable Author Statement
    more info
     
    interaction with symbiont IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interaction with symbiont via secreted substance involved in symbiotic interaction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modification by host of symbiont morphology or physiology via secreted substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modification by host of symbiont morphology or physiology via secreted substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell-cell adhesion mediated by cadherin TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibrinolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet degranulation TAS
    Traceable Author Statement
    more info
     
    positive regulation of fibrinolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    plasminogen
    Names
    plasmin
    NP_000292.1
    NP_001161810.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016200.1 RefSeqGene

      Range
      5001..56862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_571

    mRNA and Protein(s)

    1. NM_000301.3NP_000292.1  plasminogen isoform 1 precursor

      See identical proteins and their annotated locations for NP_000292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL109933, DR004070, M74220, X05199
      Consensus CDS
      CCDS5279.1
      UniProtKB/Swiss-Prot
      P00747
      Related
      ENSP00000308938.9, OTTHUMP00000017544, ENST00000308192.13, OTTHUMT00000042959
      Conserved Domains (4) summary
      smart00020
      Location:580803
      Tryp_SPc; Trypsin-like serine protease
      smart00130
      Location:101183
      KR; Kringle domain
      cd00190
      Location:581804
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01099
      Location:3897
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
    2. NM_001168338.1NP_001161810.1  plasminogen isoform 2 precursor

      See identical proteins and their annotated locations for NP_001161810.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.
      Source sequence(s)
      AL109933, DR004070
      Consensus CDS
      CCDS55074.1
      UniProtKB/TrEMBL
      Q5TEH5
      Related
      ENSP00000355891.2, OTTHUMP00000017545, ENST00000366924.6, OTTHUMT00000042960
      Conserved Domains (2) summary
      cd01099
      Location:3897
      PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...
      cl00100
      Location:102136
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      160702193..160754054
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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