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    NTF3 neurotrophin 3 [ Bos taurus (cattle) ]

    Gene ID: 532393, updated on 2-Oct-2018

    Summary

    Official Symbol
    NTF3provided by VGNC
    Official Full Name
    neurotrophin 3provided by VGNC
    Primary source
    VGNC:VGNC:32299
    See related
    BGD:BT24718; Ensembl:ENSBTAG00000010223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    NT-3
    Orthologs

    Genomic context

    See NTF3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 5 NC_037332.1 (104745600..104823265, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 5 AC_000162.1 (105140257..105217756, complement)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112446761 Neighboring gene von Willebrand factor Neighboring gene DnaJ homolog, subfamily C, member 19-like pseudogene Neighboring gene anoctamin 2 Neighboring gene uncharacterized LOC104972566 Neighboring gene uncharacterized LOC112446625 Neighboring gene uncharacterized LOC112446626

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    induction of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin cytoskeleton reorganization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077988.2NP_001071456.1  neurotrophin-3 precursor

      See identical proteins and their annotated locations for NP_001071456.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123576
      UniProtKB/Swiss-Prot
      Q08DT3
      Related
      ENSBTAP00000040469.3, ENSBTAT00000013493.5
      Conserved Domains (1) summary
      pfam00243
      Location:140249
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      104745600..104823265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024991870.1XP_024847638.1  neurotrophin-3 isoform X1

      Conserved Domains (1) summary
      pfam00243
      Location:153262
      NGF; Nerve growth factor family
    2. XM_015471319.2XP_015326805.1  neurotrophin-3 isoform X2

      UniProtKB/Swiss-Prot
      Q08DT3
      Conserved Domains (1) summary
      pfam00243
      Location:140249
      NGF; Nerve growth factor family
    3. XM_015471318.2XP_015326804.1  neurotrophin-3 isoform X2

      UniProtKB/Swiss-Prot
      Q08DT3
      Conserved Domains (1) summary
      pfam00243
      Location:140249
      NGF; Nerve growth factor family
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