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    TLR8 toll like receptor 8 [ Bos taurus (cattle) ]

    Gene ID: 532262, updated on 29-Jan-2019

    Summary

    Gene symbol
    TLR8
    Gene description
    toll like receptor 8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See TLR8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) X NC_037357.1 (130728235..130745827, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) X AC_000187.1 (141002526..141020577, complement)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene thymosin beta 4 X-linked Neighboring gene uncharacterized LOC107132093 Neighboring gene toll like receptor 7 Neighboring gene phosphoribosyl pyrophosphate synthetase 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

    General gene information

    Markers

    Homology

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033937.1NP_001029109.1  toll-like receptor 8 precursor

      See identical proteins and their annotated locations for NP_001029109.1

      Status: PROVISIONAL

      Source sequence(s)
      AY642125
      UniProtKB/TrEMBL
      Q3MND9
      Conserved Domains (5) summary
      smart00082
      Location:755803
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:863999
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:57332
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:624683
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      130728235..130745827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005228490.4XP_005228547.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005228547.1

      UniProtKB/TrEMBL
      F1APT0
      Conserved Domains (5) summary
      TIGR00864
      Location:734817
      PCC; polycystin cation channel protein
      smart00255
      Location:8721008
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:496766
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:62587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    2. XM_005228489.4XP_005228546.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005228546.1

      UniProtKB/TrEMBL
      F1APT0
      Conserved Domains (5) summary
      TIGR00864
      Location:734817
      PCC; polycystin cation channel protein
      smart00255
      Location:8721008
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:496766
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:62587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    3. XM_005228488.4XP_005228545.1  toll-like receptor 8 isoform X1

      See identical proteins and their annotated locations for XP_005228545.1

      UniProtKB/TrEMBL
      F1APT0
      Conserved Domains (5) summary
      TIGR00864
      Location:734817
      PCC; polycystin cation channel protein
      smart00255
      Location:8721008
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:496766
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:62587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    4. XM_024988093.1XP_024843861.1  toll-like receptor 8 isoform X1

      Conserved Domains (5) summary
      TIGR00864
      Location:734817
      PCC; polycystin cation channel protein
      smart00255
      Location:8721008
      TIR; Toll - interleukin 1 - resistance
      COG4886
      Location:496766
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:6285
      LRR_RI; leucine-rich repeat [structural motif]
      cl26793
      Location:62587
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
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