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    PIP prolactin induced protein [ Homo sapiens (human) ]

    Gene ID: 5304, updated on 8-Jul-2021

    Summary

    Official Symbol
    PIPprovided by HGNC
    Official Full Name
    prolactin induced proteinprovided by HGNC
    Primary source
    HGNC:HGNC:8993
    See related
    Ensembl:ENSG00000159763 MIM:176720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPIP4; GCDFP15; GCDFP-15
    Expression
    Restricted expression toward salivary gland (RPKM 2757.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PIP in Genome Data Viewer
    Location:
    7q34
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (143132077..143139739)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142829170..142836832)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily V member 1 Neighboring gene olfactory receptor family 6 subfamily W member 1 pseudogene Neighboring gene taste 2 receptor member 39 Neighboring gene taste 2 receptor member 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Gross cystic disease fluid protein-15 (GCDFP-15) binds to CD4, a T-cell co-receptor involved in antigen recognition, thereby inhibiting the ability of the receptor to interact with the HIV-1 envelope protein gp120 PubMed
    env Binding of HIV-1 envelope protein gp120 to CD4 downregulates Bcl-2 expression; this effect is inhibited by gp17/GCDFP-15, which blocks the ability of CD4 to interact with gp120, leading to moderate up-regulation of Bcl-2 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aspartic-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    prolactin-inducible protein
    Names
    SABP
    gross cystic disease fluid protein 15
    secretory actin-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002652.3NP_002643.1  prolactin-inducible protein precursor

      See identical proteins and their annotated locations for NP_002643.1

      Status: VALIDATED

      Source sequence(s)
      AC093659, Y10179
      Consensus CDS
      CCDS34768.1
      UniProtKB/Swiss-Prot
      P12273
      Related
      ENSP00000291009.3, ENST00000291009.4
      Conserved Domains (1) summary
      pfam05326
      Location:4126
      SVA; Seminal vesicle autoantigen (SVA)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      143132077..143139739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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