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    EGF epidermal growth factor [ Bos taurus (cattle) ]

    Gene ID: 530315, updated on 8-Aug-2018

    Summary

    Gene symbol
    EGF
    Gene description
    epidermal growth factor
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See EGF in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 6 NC_037333.1 (15415036..15518720, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 6 AC_000163.1 (16564317..16669065, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene uncharacterized LOC112447040 Neighboring gene ELOVL fatty acid elongase 6 Neighboring gene 60S ribosomal protein L30-like Neighboring gene 40S ribosomal protein S26 pseudogene Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

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    • Breast cancer, conserved biosystem (from KEGG)
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    • Choline metabolism in cancer, conserved biosystem (from KEGG)
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    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
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    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
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    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
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    • Endocytosis, organism-specific biosystem (from KEGG)
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    • Endocytosis, conserved biosystem (from KEGG)
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    • Endometrial cancer, organism-specific biosystem (from KEGG)
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    • Endometrial cancer, conserved biosystem (from KEGG)
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    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
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    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
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    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
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    • Hepatitis C, organism-specific biosystem (from KEGG)
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    • Hepatitis C, conserved biosystem (from KEGG)
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    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
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    • Melanoma, organism-specific biosystem (from KEGG)
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    • Melanoma, conserved biosystem (from KEGG)
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    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
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    • Non-small cell lung cancer, conserved biosystem (from KEGG)
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    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
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    • Pancreatic cancer, organism-specific biosystem (from KEGG)
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    • Pancreatic cancer, conserved biosystem (from KEGG)
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    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
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    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
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    • Prostate cancer, organism-specific biosystem (from KEGG)
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    • Prostate cancer, conserved biosystem (from KEGG)
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    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
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    • Rap1 signaling pathway, conserved biosystem (from KEGG)
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    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    pro-epidermal growth factor; LOW QUALITY PROTEIN: pro-epidermal growth factor
    Names
    epidermal growth factor (beta-urogastrone)

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      15415036..15518720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993778.1XP_024849546.1  LOW QUALITY PROTEIN: pro-epidermal growth factor

      Conserved Domains (3) summary
      smart00135
      Location:516557
      LY; Low-density lipoprotein-receptor YWTD domain
      pfam12947
      Location:857886
      EGF_3; EGF domain
      pfam14670
      Location:713748
      FXa_inhibition; Coagulation Factor Xa inhibitory site
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