Format

Send to:

Choose Destination
    • Showing Current items.

    PGC progastricsin [ Homo sapiens (human) ]

    Gene ID: 5225, updated on 9-Sep-2018

    Summary

    Official Symbol
    PGCprovided by HGNC
    Official Full Name
    progastricsinprovided by HGNC
    Primary source
    HGNC:HGNC:8890
    See related
    Ensembl:ENSG00000096088 MIM:169740; Vega:OTTHUMG00000014683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PEPC; PGII
    Summary
    This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
    Expression
    Restricted expression toward stomach (RPKM 7385.5) See more
    Orthologs

    Genomic context

    See PGC in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (41736711..41747401, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41704449..41715139, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1 pseudogene 51 Neighboring gene transcription factor EB Neighboring gene fibroblast growth factor receptor substrate 3 Neighboring gene prickle planar cell polarity protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ99563

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    aspartic-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    digestion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of antibacterial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gastricsin
    Names
    pepsin C
    pepsinogen C
    pepsinogen group II
    preprogastricsin
    NP_001159896.1
    NP_002621.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166424.1NP_001159896.1  gastricsin isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001159896.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK301298, AL365205
      Consensus CDS
      CCDS55000.1
      UniProtKB/Swiss-Prot
      P20142
      Related
      ENSP00000405094.2, ENST00000425343.6
      Conserved Domains (2) summary
      pfam07966
      Location:1846
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:70216
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    2. NM_002630.3NP_002621.1  gastricsin isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_002621.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL365205, BC073740
      Consensus CDS
      CCDS4859.1
      UniProtKB/Swiss-Prot
      P20142
      Related
      ENSP00000362116.3, OTTHUMP00000016377, ENST00000373025.7, OTTHUMT00000040521
      Conserved Domains (3) summary
      cd05477
      Location:70387
      gastricsin; Gastricsins, asparate proteases produced in gastric mucosa
      pfam00026
      Location:72387
      Asp; Eukaryotic aspartyl protease
      pfam07966
      Location:1846
      A1_Propeptide; A1 Propeptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      41736711..41747401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center