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    MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 [ Bos taurus (cattle) ]

    Gene ID: 522002, updated on 27-Aug-2018

    Summary

    Official Symbol
    MAP4K1provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:31204
    See related
    Ensembl:ENSBTAG00000021145
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See MAP4K1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 18 NC_037345.1 (48365445..48382095, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 18 AC_000175.1 (48633598..48647723, complement)

    Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene RAS guanyl releasing protein 4 Neighboring gene ryanodine receptor 1 Neighboring gene microRNA 2329-2 Neighboring gene microRNA 2329-1 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene uncharacterized LOC112442312 Neighboring gene actinin alpha 4

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
    • Cardiac Hypertrophic Response, organism-specific biosystem (from WikiPathways)
      Cardiac Hypertrophic Response, organism-specific biosystemIntegrated schematic of the more extensively characterized intracellular signal-transduction pathways that coordinate the cardiac hypertrophic response. During development and in response to physiolo...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
      Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
      Signaling of Hepatocyte Growth Factor Receptor
    • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • TGF beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...

    General gene information

    Homology

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 1
    NP_001069293.2
    XP_024834039.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075825.2NP_001069293.2  mitogen-activated protein kinase kinase kinase kinase 1

      See identical proteins and their annotated locations for NP_001069293.2

      Status: PROVISIONAL

      Source sequence(s)
      BC149646, BT026208
      UniProtKB/TrEMBL
      A6QQ50, Q0V8L0
      Related
      ENSBTAP00000028180.5, ENSBTAT00000028180.5
      Conserved Domains (3) summary
      smart00036
      Location:499806
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:17274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037345.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      48365445..48382095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024978271.1XP_024834039.1  mitogen-activated protein kinase kinase kinase kinase 1 isoform X1

      Conserved Domains (2) summary
      smart00036
      Location:499807
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:16274
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
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