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    LAMB2 laminin, beta 2 (laminin S) [ Bos taurus (cattle) ]

    Gene ID: 520167, updated on 27-Aug-2018

    Summary

    Gene symbol
    LAMB2
    Gene description
    laminin, beta 2 (laminin S)
    See related
    Ensembl:ENSBTAG00000022635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos

    Genomic context

    See LAMB2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 22 NC_037349.1 (50883580..50897890)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (51456152..51470445)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene laminin subunit beta-2 Neighboring gene laminin subunit beta-2-like Neighboring gene ubiquitin specific peptidase 19 Neighboring gene glutaminyl-tRNA synthetase

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Alpha 6 Beta 4 signaling pathway, organism-specific biosystem (from WikiPathways)
      Alpha 6 Beta 4 signaling pathway, organism-specific biosystemThe integrin alpha6beta4 was discovered in the late 1980s by two different groups and was called either alphaEbeta4 or Ic-Ic binding protein (Ic-IcBP) (1,2). The alpha6beta4 integrin is a component o...
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
      Inflammatory Response Pathway, organism-specific biosystem
      Inflammatory Response Pathway
    • Laminin interactions, organism-specific biosystem (from REACTOME)
      Laminin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MET activates PTK2 signaling, organism-specific biosystem (from REACTOME)
      MET activates PTK2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MET promotes cell motility, organism-specific biosystem (from REACTOME)
      MET promotes cell motility, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystem (from WikiPathways)
      Primary Focal Segmental Glomerulosclerosis FSGS, organism-specific biosystemPrimary or idiopathic focal segmental glomerulosclerosis (FSGS) a cause of nephrotic syndrome in children and adolescents, as well as an important cause of end stage renal disease in adults. FSGS is ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC128643

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001046247.2NP_001039712.2  laminin subunit beta-2 precursor

      Status: VALIDATED

      Source sequence(s)
      BC105436, CK963940, DT810209, DT811149, DV875815, DV920193, EE366453, EE385105, EH174117, EV706949
      UniProtKB/TrEMBL
      Q2KJA7
      Related
      ENSBTAP00000051130.2, ENSBTAT00000057452.2
      Conserved Domains (7) summary
      smart00180
      Location:787832
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:525566
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:11471186
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:61285
      Laminin_N; Laminin N-terminal (Domain VI)
      pfam12795
      Location:14821777
      MscS_porin; Mechanosensitive ion channel porin domain
      cl02193
      Location:15551744
      VirB5_like; VirB5 protein family
      cl21478
      Location:14571545
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      50883580..50897890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010817733.3XP_010816035.2  laminin subunit beta-2 isoform X1

      Conserved Domains (5) summary
      smart00180
      Location:787832
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:525566
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00053
      Location:10721111
      Laminin_EGF; Laminin EGF domain
      pfam00055
      Location:65285
      Laminin_N; Laminin N-terminal (Domain VI)
      cl25732
      Location:11271717
      SMC_N; RecF/RecN/SMC N terminal domain
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