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    PFDN1 prefoldin subunit 1 [ Homo sapiens (human) ]

    Gene ID: 5201, updated on 7-Oct-2018

    Summary

    Official Symbol
    PFDN1provided by HGNC
    Official Full Name
    prefoldin subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:8866
    See related
    Ensembl:ENSG00000113068 MIM:604897; Vega:OTTHUMG00000129249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDF; PFD1
    Summary
    This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 19.4), fat (RPKM 19.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See PFDN1 in Genome Data Viewer
    Location:
    5q31.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (140245050..140303104, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139624635..139682689, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929719 Neighboring gene cysteine rich transmembrane module containing 1 Neighboring gene heparin binding EGF like growth factor Neighboring gene solute carrier family 4 member 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding involved in protein folding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prefoldin subunit 1
    Names
    prefoldin 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002622.4NP_002613.2  prefoldin subunit 1

      See identical proteins and their annotated locations for NP_002613.2

      Status: REVIEWED

      Source sequence(s)
      AA910992, AC011380, BG707314
      Consensus CDS
      CCDS4222.1
      UniProtKB/Swiss-Prot
      O60925
      Related
      ENSP00000261813.4, OTTHUMP00000159560, ENST00000261813.8, OTTHUMT00000251354
      Conserved Domains (1) summary
      pfam01920
      Location:14117
      Prefoldin_2; Prefoldin subunit

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      140245050..140303104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268465.4XP_005268522.1  prefoldin subunit 1 isoform X1

      Conserved Domains (1) summary
      pfam01920
      Location:14100
      Prefoldin_2; Prefoldin subunit
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