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    MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 [ Bos taurus (cattle) ]

    Gene ID: 520058, updated on 27-Aug-2018

    Summary

    Official Symbol
    MAP4K2provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:31205
    See related
    BGD:BT26942; Ensembl:ENSBTAG00000001037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See MAP4K2 in Genome Data Viewer
    Location:
    chromosome: 29
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 29 NC_037356.1 (43022822..43040946, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 29 AC_000186.1 (43646715..43661396, complement)

    Chromosome 29 - NC_037356.1Genomic Context describing neighboring genes Neighboring gene splicing factor 1 Neighboring gene uncharacterized LOC101902942 Neighboring gene menin 1 Neighboring gene CDC42 binding protein kinase gamma

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 2
    NP_001193204.1
    XP_024842925.1
    XP_024842926.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206275.1NP_001193204.1  mitogen-activated protein kinase kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_001193204.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000029
      Related
      ENSBTAP00000001378.4, ENSBTAT00000001378.4
      Conserved Domains (3) summary
      smart00036
      Location:488800
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:16272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:16272
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037356.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      43022822..43040946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024987157.1XP_024842925.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X1

      Conserved Domains (2) summary
      smart00036
      Location:488789
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:16272
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases
    2. XM_024987158.1XP_024842926.1  mitogen-activated protein kinase kinase kinase kinase 2 isoform X2

      Conserved Domains (2) summary
      smart00036
      Location:395707
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:12179
      PKc_like; Protein Kinases, catalytic domain
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