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    SIRT6 sirtuin 6 [ Homo sapiens (human) ]

    Gene ID: 51548, updated on 6-Sep-2021

    Summary

    Official Symbol
    SIRT6provided by HGNC
    Official Full Name
    sirtuin 6provided by HGNC
    Primary source
    HGNC:HGNC:14934
    See related
    Ensembl:ENSG00000077463 MIM:606211
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2L6
    Summary
    This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in colon (RPKM 11.3), spleen (RPKM 5.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SIRT6 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4174109..4182563, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4174106..4182560, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 6873 Neighboring gene cAMP responsive element binding protein 3 like 3 Neighboring gene ankyrin repeat domain 24 Neighboring gene Epstein-Barr virus induced 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD(P)+-protein-arginine ADP-ribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD+ ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NAD+ binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD-dependent histone deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity TAS
    Traceable Author Statement
    more info
     
    enables deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in histone H3 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H3-K9 deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H3-K9 modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of blood vessel branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription factor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-embryonic cardiac muscle cell growth involved in heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ADP-ribosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ADP-ribosylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-6
    Names
    SIR2-like protein 6
    regulatory protein SIR2 homolog 6
    sir2-related protein type 6
    sirtuin type 6
    NP_001180214.1
    NP_001307987.1
    NP_001307988.1
    NP_001307989.1
    NP_001307990.1
    NP_001307991.1
    NP_001307992.1
    NP_001307993.1
    NP_057623.2
    XP_024307307.1
    XP_024307308.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047153.1 RefSeqGene

      Range
      5037..13491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193285.3NP_001180214.1  NAD-dependent protein deacetylase sirtuin-6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC006930, AC016586, BC028220, CN364177
      Consensus CDS
      CCDS54199.1
      UniProtKB/Swiss-Prot
      Q8N6T7
      Related
      ENSP00000305310.5, ENST00000305232.10
      Conserved Domains (1) summary
      cl00195
      Location:45230
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    2. NM_001321058.2NP_001307987.1  NAD-dependent protein deacetylase sirtuin-6 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC016586, AK293348, BC028220
      UniProtKB/Swiss-Prot
      Q8N6T7
      UniProtKB/TrEMBL
      B4DDV3
      Conserved Domains (1) summary
      cl00195
      Location:1185
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. NM_001321059.2NP_001307988.1  NAD-dependent protein deacetylase sirtuin-6 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006930, AK225567, BC028220, BQ060703, CN364177
      UniProtKB/Swiss-Prot
      Q8N6T7
      Related
      ENSP00000470215.1, ENST00000597896.5
      Conserved Domains (1) summary
      cl00195
      Location:45196
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    4. NM_001321060.2NP_001307989.1  NAD-dependent protein deacetylase sirtuin-6 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC006930, AK225567, BC028220, CN364175, CN364177
      UniProtKB/Swiss-Prot
      Q8N6T7
      Conserved Domains (1) summary
      cl00195
      Location:45205
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    5. NM_001321061.2NP_001307990.1  NAD-dependent protein deacetylase sirtuin-6 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC016586, BC004218, BC028220, CN364177
      UniProtKB/Swiss-Prot
      Q8N6T7
      Conserved Domains (1) summary
      cl00195
      Location:1158
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    6. NM_001321062.2NP_001307991.1  NAD-dependent protein deacetylase sirtuin-6 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC006930, AK225567, BC028220, BP418952, CN364177
      UniProtKB/Swiss-Prot
      Q8N6T7
      Conserved Domains (1) summary
      cl00195
      Location:1122
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    7. NM_001321063.2NP_001307992.1  NAD-dependent protein deacetylase sirtuin-6 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC006930, AK225567, BC028220, BE281103, CN364177
      Consensus CDS
      CCDS82276.1
      UniProtKB/Swiss-Prot
      Q8N6T7
      UniProtKB/TrEMBL
      M0QXA0
      Related
      ENSP00000469001.1, ENST00000601488.5
      Conserved Domains (1) summary
      cl00195
      Location:45144
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    8. NM_001321064.2NP_001307993.1  NAD-dependent protein deacetylase sirtuin-6 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC006930, AK074810, AL559383, BC028220
      Consensus CDS
      CCDS82275.1
      UniProtKB/Swiss-Prot
      Q8N6T7
      UniProtKB/TrEMBL
      M0R1N9
      Related
      ENSP00000472023.1, ENST00000594279.5
      Conserved Domains (1) summary
      cl00195
      Location:1133
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    9. NM_016539.4NP_057623.2  NAD-dependent protein deacetylase sirtuin-6 isoform 1

      See identical proteins and their annotated locations for NP_057623.2

      Status: REVIEWED

      Source sequence(s)
      AK074810, BC005026, CN364177
      Consensus CDS
      CCDS12122.1
      UniProtKB/Swiss-Prot
      Q8N6T7
      Related
      ENSP00000337332.1, ENST00000337491.7
      Conserved Domains (1) summary
      cd01410
      Location:45257
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      4174109..4182563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451540.1XP_024307308.1  NAD-dependent protein deacetylase sirtuin-6 isoform X2

      Conserved Domains (1) summary
      cl00195
      Location:1133
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    2. XM_024451539.1XP_024307307.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

      Conserved Domains (1) summary
      cl00195
      Location:42233
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
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