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    IRAK2 interleukin 1 receptor associated kinase 2 [ Bos taurus (cattle) ]

    Gene ID: 515034, updated on 21-Jan-2019

    Summary

    Official Symbol
    IRAK2provided by VGNC
    Official Full Name
    interleukin 1 receptor associated kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:30266
    See related
    BGD:BT12015; Ensembl:ENSBTAG00000006193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    IRAK-2
    Orthologs

    Genomic context

    See IRAK2 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 22 NC_037349.1 (16649507..16705570, complement)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (16694670..16750676, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene ribonuclease H2 subunit B pseudogene Neighboring gene uncharacterized LOC101906342 Neighboring gene TatD DNase domain containing 2 Neighboring gene uncharacterized LOC112443428 Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene BRICK1 subunit of SCAR/WAVE actin nucleating complex

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-1 receptor-associated kinase-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075696.2NP_001069164.1  interleukin-1 receptor-associated kinase-like 2

      See identical proteins and their annotated locations for NP_001069164.1

      Status: PROVISIONAL

      Source sequence(s)
      BC120001
      UniProtKB/Swiss-Prot
      Q0P5I2
      Related
      ENSBTAP00000008135.5, ENSBTAT00000008135.6
      Conserved Domains (3) summary
      cd08795
      Location:391
      Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2
      pfam00069
      Location:206438
      Pkinase; Protein kinase domain
      cl21453
      Location:212500
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      16649507..16705570 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024982661.1XP_024838429.1  interleukin-1 receptor-associated kinase-like 2 isoform X2

      Related
      ENSBTAP00000061924.1, ENSBTAT00000084740.1
      Conserved Domains (2) summary
      cl14633
      Location:336
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl21453
      Location:151439
      PKc_like; Protein Kinases, catalytic domain
    2. XM_024982660.1XP_024838428.1  interleukin-1 receptor-associated kinase-like 2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:192480
      PKc_like; Protein Kinases, catalytic domain
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