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    GPR89B G protein-coupled receptor 89B [ Homo sapiens (human) ]

    Gene ID: 51463, updated on 5-Aug-2018

    Summary

    Official Symbol
    GPR89Bprovided by HGNC
    Official Full Name
    G protein-coupled receptor 89Bprovided by HGNC
    Primary source
    HGNC:HGNC:13840
    See related
    Ensembl:ENSG00000188092 MIM:612806; Vega:OTTHUMG00000013452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPHR; GPR89; SH120; GPR89C; UNQ192
    Annotation information
    Note: There are multiple copies of the sequence G protein-coupled receptor 89 in the human genome. After consultation with the HUGO Gene Nomenclature committee, the symbol GPR89B was assigned to the most telomeric locus. [06 Jun 2007]
    Expression
    Ubiquitous expression in kidney (RPKM 17.6), testis (RPKM 13.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See GPR89B in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (147928374..147993592)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (147400506..147465753)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 17 pseudogene Neighboring gene uncharacterized LOC105371229 Neighboring gene gap junction protein alpha 8 Neighboring gene PDZ domain containing 1 pseudogene 1 Neighboring gene uncharacterized LOC105371228 Neighboring gene transfer RNA-Arg (CCT) 6-2 Neighboring gene RNA, U1 small nuclear 129, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ55546, FLJ61382

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    voltage-gated anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular pH reduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi cisterna membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Golgi pH regulator B
    Names
    G protein-coupled receptor 89C
    Golgi pH regulator A
    protein GPR89
    putative Golgi pH regulator C
    putative MAPK-activating protein PM01
    putative NF-kappa-B-activating protein 90
    putative protein GPR89C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001350180.1NP_001337109.1  Golgi pH regulator B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon structure in the 3' region compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AL133020, AW002571, AW137222, DB524598, DC412954, U78723
      Consensus CDS
      CCDS930.1
      Conserved Domains (2) summary
      pfam12430
      Location:276444
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:140207
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    2. NM_001350181.1NP_001337110.1  Golgi pH regulator B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AL133020, AW002571, AW137222, DB459108, DC412954, U78723
      Conserved Domains (2) summary
      pfam12430
      Location:251419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    3. NM_001350182.1NP_001337111.1  Golgi pH regulator B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      AL133020, AW002571, AW137222, DC345007, DC412954, U78723
      Conserved Domains (2) summary
      pfam12430
      Location:251419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    4. NM_001350183.1NP_001337112.1  Golgi pH regulator B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3).
      Source sequence(s)
      AL133020, AW002571, AW137222, DA922006, DC412954, U78723
      Conserved Domains (2) summary
      pfam12430
      Location:156324
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:2087
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    5. NM_001350184.1NP_001337113.1  Golgi pH regulator B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon and uses an alternate splice site in its 5' region, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 3)
      Source sequence(s)
      AL133020, AW002571, AW137222, DA065783, DA922006, DC412954, U78723
      Conserved Domains (2) summary
      pfam12430
      Location:156324
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:2087
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    6. NM_016334.4NP_057418.1  Golgi pH regulator B isoform 1

      See identical proteins and their annotated locations for NP_057418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AL133020, AW002571, AW137222, DC412954, U78723
      Consensus CDS
      CCDS930.1
      UniProtKB/Swiss-Prot
      B7ZAQ6, P0CG08
      UniProtKB/TrEMBL
      X5D7G6
      Related
      ENSP00000358233.4, OTTHUMP00000015424, ENST00000314163.11
      Conserved Domains (2) summary
      pfam12430
      Location:276444
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:140207
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      147928374..147993592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001449.1XP_016856938.1  Golgi pH regulator B isoform X3

    2. XM_011509613.2XP_011507915.1  Golgi pH regulator B isoform X4

      See identical proteins and their annotated locations for XP_011507915.1

      UniProtKB/Swiss-Prot
      P0CG08
      Related
      ENSP00000475253.1, OTTHUMP00000273549, ENST00000468618.6, OTTHUMT00000157352
      Conserved Domains (1) summary
      pfam12537
      Location:140207
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    3. XM_017001448.2XP_016856937.1  Golgi pH regulator B isoform X1

      UniProtKB/Swiss-Prot
      B7ZAQ6
      Conserved Domains (2) summary
      pfam12430
      Location:251419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    4. XM_005277402.4XP_005277459.1  Golgi pH regulator B isoform X1

      See identical proteins and their annotated locations for XP_005277459.1

      UniProtKB/Swiss-Prot
      B7ZAQ6
      Conserved Domains (2) summary
      pfam12430
      Location:251419
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:115182
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal
    5. XM_011509612.2XP_011507914.1  Golgi pH regulator B isoform X2

      See identical proteins and their annotated locations for XP_011507914.1

      UniProtKB/Swiss-Prot
      B7ZAQ6
      Conserved Domains (2) summary
      pfam12430
      Location:156324
      ABA_GPCR; Abscisic acid G-protein coupled receptor
      pfam12537
      Location:2087
      GPHR_N; The Golgi pH Regulator (GPHR) Family N-terminal

    RNA

    1. XR_001737221.1 RNA Sequence

      Related
      ENST00000488165.5, OTTHUMT00000037483

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001097616.1: Suppressed sequence

      Description
      NM_001097616.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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