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    MRPL35 mitochondrial ribosomal protein L35 [ Homo sapiens (human) ]

    Gene ID: 51318, updated on 8-Apr-2018
    Official Symbol
    MRPL35provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L35provided by HGNC
    Primary source
    HGNC:HGNC:14489
    See related
    Ensembl:ENSG00000132313 MIM:611841; Vega:OTTHUMG00000037385
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L35mt; MRP-L35
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 19.0), colon (RPKM 15.8) and 25 other tissues See more
    Orthologs
    Location:
    2p11.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (86199433..86213798)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86426478..86440913)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene inner membrane mitochondrial protein Neighboring gene microRNA 4779 Neighboring gene receptor accessory protein 1 Neighboring gene lysine demethylase 3A

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    • Mitochondrial translation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
    • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
    • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
    • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
      Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Ribosome, organism-specific biosystem (from KEGG)
      Ribosome, organism-specific biosystem
      Ribosome
    • Ribosome, conserved biosystem (from KEGG)
      Ribosome, conserved biosystem
      Ribosome
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial translational elongation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational termination TAS
    Traceable Author Statement
    more info
     
    translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    39S ribosomal protein L35, mitochondrial
    Names
    mitochondrial large ribosomal subunit protein bL35m

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016622.3NP_057706.2  39S ribosomal protein L35, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_057706.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), with the upstream polyadenylation site, is the predominant transcript and encodes isoform a.
      Source sequence(s)
      AL832982, BG108475, BQ421154, BQ879834, BU195549, DA413384, DA443416, DB245340, F11007, H11039
      Consensus CDS
      CCDS1988.1
      UniProtKB/Swiss-Prot
      Q9NZE8
      Related
      ENSP00000338389.4, OTTHUMP00000035512, ENST00000337109.8, OTTHUMT00000091002
      Conserved Domains (1) summary
      pfam01632
      Location:102161
      Ribosomal_L35p; Ribosomal protein L35
    2. NM_145644.2NP_663619.1  39S ribosomal protein L35, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_663619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1, that causes a frameshift and a shorter 3' UTR. The resulting isoform (b) has a shorter C-terminus when compared to isoform a.
      Source sequence(s)
      AK314577, AL832982, BC020651, BU195549, DA413384, F11007, H11039
      Consensus CDS
      CCDS1987.1
      UniProtKB/Swiss-Prot
      Q9NZE8
      Related
      ENSP00000254644.7, OTTHUMP00000035511, ENST00000254644.12, OTTHUMT00000091001
      Conserved Domains (1) summary
      pfam01632
      Location:102161
      Ribosomal_L35p; Ribosomal protein L35

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      86199433..86213798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264361.3XP_005264418.1  39S ribosomal protein L35, mitochondrial isoform X1

      UniProtKB/TrEMBL
      D3YTC1
      Related
      ENSP00000386255.1, OTTHUMP00000203313, ENST00000409180.1
      Conserved Domains (1) summary
      pfam01632
      Location:102161
      Ribosomal_L35p; Ribosomal protein L35
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