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    EPHA2 EPH receptor A2 [ Bos taurus (cattle) ]

    Gene ID: 512798, updated on 27-Aug-2018

    Summary

    Official Symbol
    EPHA2provided by VGNC
    Official Full Name
    EPH receptor A2provided by VGNC
    Primary source
    VGNC:VGNC:28534
    See related
    BGD:BT23135; Ensembl:ENSBTAG00000000815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See EPHA2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 2 NC_037329.1 (135945217..135972064)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 2 AC_000159.1 (136525537..136552381)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene ciliogenesis and planar polarity effector 2 Neighboring gene Rho guanine nucleotide exchange factor 19 Neighboring gene uncharacterized LOC112443516 Neighboring gene basic salivary proline-rich protein 1-like Neighboring gene U6 spliceosomal RNA Neighboring gene family with sequence similarity 131 member C

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
      EPH-Ephrin signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
      EPH-ephrin mediated repulsion of cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
      EPHA-mediated growth cone collapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...

    General gene information

    Homology

    General protein information

    Preferred Names
    ephrin type-A receptor 2
    NP_001192660.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205731.3NP_001192660.1  ephrin type-A receptor 2 precursor

      See identical proteins and their annotated locations for NP_001192660.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000002
      UniProtKB/TrEMBL
      E1BJ31
      Related
      ENSBTAP00000001080.4, ENSBTAT00000001080.4
      Conserved Domains (7) summary
      cd09543
      Location:901970
      SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
      smart00454
      Location:901967
      SAM; Sterile alpha motif
      cd10480
      Location:28201
      EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
      pfam00041
      Location:438519
      fn3; Fibronectin type III domain
      pfam07714
      Location:613870
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:554608
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl21453
      Location:607874
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      135945217..135972064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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