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    CDK16 cyclin dependent kinase 16 [ Homo sapiens (human) ]

    Gene ID: 5127, updated on 5-Sep-2021

    Summary

    Official Symbol
    CDK16provided by HGNC
    Official Full Name
    cyclin dependent kinase 16provided by HGNC
    Primary source
    HGNC:HGNC:8749
    See related
    Ensembl:ENSG00000102225 MIM:311550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE
    Summary
    The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
    Expression
    Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 14.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDK16 in Genome Data Viewer
    Location:
    Xp11.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47217881..47229997)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47077702..47089396)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 10 Neighboring gene ITPK1 pseudogene 1 Neighboring gene uncharacterized LOC105373194 Neighboring gene ubiquitin like modifier activating enzyme 1 Neighboring gene inactivation escape 1 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element Neighboring gene ubiquitin specific peptidase 11 Neighboring gene nicolin 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of cyclin-dependent kinase 16 (CDK16; PCTAIRE) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ16665

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in growth hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cyclin-dependent kinase 16
    Names
    PCTAIRE-motif protein kinase 1
    cell division protein kinase 16
    serine/threonine-protein kinase PCTAIRE-1
    testis secretory sperm-binding protein Li 224n
    NP_001163931.1
    NP_006192.1
    NP_148978.2
    XP_011542222.1
    XP_011542223.1
    XP_011542224.1
    XP_011542225.1
    XP_011542226.1
    XP_011542227.1
    XP_011542228.1
    XP_011542229.1
    XP_011542230.1
    XP_016885058.1
    XP_016885059.1
    XP_016885060.1
    XP_016885061.1
    XP_016885062.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012517.2 RefSeqGene

      Range
      5175..16869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170460.2NP_001163931.1  cyclin-dependent kinase 16 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 3, which has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK096881, AK290145, AK301832, BC006190
      Consensus CDS
      CCDS55408.1
      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      Q9BRL4
      Related
      ENSP00000276052.6, ENST00000276052.10
      Conserved Domains (2) summary
      PLN00009
      Location:236524
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07873
      Location:236532
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    2. NM_006201.5NP_006192.1  cyclin-dependent kinase 16 isoform 1

      See identical proteins and their annotated locations for NP_006192.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shortest isoform (1).
      Source sequence(s)
      AK096881, AK290145, BC006190, DA816614
      Consensus CDS
      CCDS14276.1
      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      A0A140VK97, Q9BRL4
      Related
      ENSP00000349762.4, ENST00000357227.9
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    3. NM_033018.4NP_148978.2  cyclin-dependent kinase 16 isoform 2

      See identical proteins and their annotated locations for NP_148978.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 2, which has a longer and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC015607, BQ187876
      Consensus CDS
      CCDS48101.1
      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      A0A024R183
      Related
      ENSP00000405798.2, ENST00000457458.6
      Conserved Domains (1) summary
      cd07873
      Location:168464
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      47217881..47229997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029573.1XP_016885062.1  cyclin-dependent kinase 16 isoform X7

      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      A0A140VK97
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    2. XM_011543928.1XP_011542230.1  cyclin-dependent kinase 16 isoform X6

      See identical proteins and their annotated locations for XP_011542230.1

      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    3. XM_017029569.1XP_016885058.1  cyclin-dependent kinase 16 isoform X3

    4. XM_011543921.1XP_011542223.1  cyclin-dependent kinase 16 isoform X2

      See identical proteins and their annotated locations for XP_011542223.1

      Conserved Domains (2) summary
      PLN00009
      Location:209497
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07873
      Location:209505
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    5. XM_011543922.1XP_011542224.1  cyclin-dependent kinase 16 isoform X4

      Conserved Domains (2) summary
      PLN00009
      Location:205493
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07873
      Location:205501
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    6. XM_011543923.2XP_011542225.1  cyclin-dependent kinase 16 isoform X5

      See identical proteins and their annotated locations for XP_011542225.1

      Conserved Domains (1) summary
      cd07873
      Location:168464
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    7. XM_017029572.2XP_016885061.1  cyclin-dependent kinase 16 isoform X7

      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      A0A140VK97
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    8. XM_011543927.3XP_011542229.1  cyclin-dependent kinase 16 isoform X6

      See identical proteins and their annotated locations for XP_011542229.1

      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    9. XM_017029570.2XP_016885059.1  cyclin-dependent kinase 16 isoform X7

      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      A0A140VK97
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    10. XM_011543925.3XP_011542227.1  cyclin-dependent kinase 16 isoform X6

      See identical proteins and their annotated locations for XP_011542227.1

      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    11. XM_011543924.2XP_011542226.1  cyclin-dependent kinase 16 isoform X6

      See identical proteins and their annotated locations for XP_011542226.1

      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    12. XM_017029571.1XP_016885060.1  cyclin-dependent kinase 16 isoform X7

      UniProtKB/Swiss-Prot
      Q00536
      UniProtKB/TrEMBL
      A0A140VK97
      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    13. XM_011543926.1XP_011542228.1  cyclin-dependent kinase 16 isoform X6

      See identical proteins and their annotated locations for XP_011542228.1

      Conserved Domains (1) summary
      cd07873
      Location:162458
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
    14. XM_011543920.3XP_011542222.1  cyclin-dependent kinase 16 isoform X1

      Conserved Domains (2) summary
      PLN00009
      Location:236524
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07873
      Location:236532
      STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

    RNA

    1. XR_949017.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033019.1: Suppressed sequence

      Description
      NM_033019.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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