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    TUBE1 tubulin epsilon 1 [ Homo sapiens (human) ]

    Gene ID: 51175, updated on 2-Oct-2018

    Summary

    Official Symbol
    TUBE1provided by HGNC
    Official Full Name
    tubulin epsilon 1provided by HGNC
    Primary source
    HGNC:HGNC:20775
    See related
    Ensembl:ENSG00000074935 MIM:607345; Vega:OTTHUMG00000015382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TUBE; dJ142L7.2
    Summary
    This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
    Expression
    Broad expression in testis (RPKM 21.9), endometrium (RPKM 10.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See TUBE1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (112070657..112087548, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (112391860..112408751, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377947 Neighboring gene cellular communication network factor 6 Neighboring gene family with sequence similarity 229 member B Neighboring gene uncharacterized LOC107986633 Neighboring gene laminin subunit alpha 4 Neighboring gene RNA, U6 small nuclear 1226, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
    tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22589, FLJ44203

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    centrosome cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pericentriolar material TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    tubulin epsilon chain
    Names
    epsilon-tubulin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016262.4NP_057346.1  tubulin epsilon chain

      See identical proteins and their annotated locations for NP_057346.1

      Status: REVIEWED

      Source sequence(s)
      AK026242, BC025405, CA411886, DA160210
      Consensus CDS
      CCDS5100.1
      UniProtKB/Swiss-Prot
      Q9UJT0
      Related
      ENSP00000357651.5, OTTHUMP00000017033, ENST00000368662.9, OTTHUMT00000041867
      Conserved Domains (1) summary
      cd02190
      Location:2457
      epsilon_tubulin; The epsilon-tubulin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

      Range
      112070657..112087548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535875.2XP_011534177.1  tubulin epsilon chain isoform X2

      Conserved Domains (1) summary
      cd02190
      Location:1382
      epsilon_tubulin; The epsilon-tubulin family
    2. XM_017010918.1XP_016866407.1  tubulin epsilon chain isoform X1

      Conserved Domains (1) summary
      cd02190
      Location:10413
      epsilon_tubulin; The epsilon-tubulin family
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