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    ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens (human) ]

    Gene ID: 51008, updated on 5-Sep-2021

    Summary

    Official Symbol
    ASCC1provided by HGNC
    Official Full Name
    activating signal cointegrator 1 complex subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:24268
    See related
    Ensembl:ENSG00000138303 MIM:614215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p50; CGI-18; SMABF2; ASC1p50
    Summary
    This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in testis (RPKM 7.6), brain (RPKM 6.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ASCC1 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (72096032..72218777, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73855790..73976892, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 3 Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene Sharpr-MPRA regulatory region 1217 Neighboring gene DNA damage inducible transcript 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    activating signal cointegrator 1 complex subunit 1
    Names
    ASC-1 complex subunit P50
    trip4 complex subunit p50

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031890.1 RefSeqGene

      Range
      5859..126103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198798.2NP_001185727.1  activating signal cointegrator 1 complex subunit 1 isoform b

      See identical proteins and their annotated locations for NP_001185727.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks three exons in the coding region, which results in a translational frameshift, compared to variant 1. Variants 2 and 4 encode the same isoform (b) which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC022392, BC012291, DA951859
      Consensus CDS
      CCDS31219.1
      UniProtKB/Swiss-Prot
      Q8N9N2
      UniProtKB/TrEMBL
      A0A024QZM0
      Related
      ENSP00000378377.1, ENST00000394919.5
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133356
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    2. NM_001198799.3NP_001185728.1  activating signal cointegrator 1 complex subunit 1 isoform a

      See identical proteins and their annotated locations for NP_001185728.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC022392, AK094170, DA942671
      Consensus CDS
      CCDS55713.1
      UniProtKB/Swiss-Prot
      Q8N9N2
      Related
      ENSP00000339404.4, ENST00000342444.8
      Conserved Domains (3) summary
      PLN00108
      Location:157370
      PLN00108; unknown protein; Provisional
      cd02394
      Location:99148
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:161349
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    3. NM_001198800.3NP_001185729.1  activating signal cointegrator 1 complex subunit 1 isoform b

      See identical proteins and their annotated locations for NP_001185729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three exons in the coding region, which results in a translational frameshift, compared to variant 1. Variants 2 and 4 encode the same isoform (b) which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC022392, AK023436
      Consensus CDS
      CCDS31219.1
      UniProtKB/Swiss-Prot
      Q8N9N2
      UniProtKB/TrEMBL
      A0A024QZM0
      Related
      ENSP00000500935.1, ENST00000672957.1
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133356
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    4. NM_001369085.1NP_001356014.1  activating signal cointegrator 1 complex subunit 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:84142
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:155354
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    5. NM_001369086.1NP_001356015.1  activating signal cointegrator 1 complex subunit 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:84142
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:155354
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    6. NM_001369087.1NP_001356016.1  activating signal cointegrator 1 complex subunit 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133332
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    7. NM_001369088.1NP_001356017.1  activating signal cointegrator 1 complex subunit 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133332
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    8. NM_001369089.1NP_001356018.1  activating signal cointegrator 1 complex subunit 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133332
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    9. NM_001369090.1NP_001356019.1  activating signal cointegrator 1 complex subunit 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133332
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    10. NM_001369091.1NP_001356020.1  activating signal cointegrator 1 complex subunit 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133332
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    11. NM_001369092.1NP_001356021.1  activating signal cointegrator 1 complex subunit 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133332
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    12. NM_001369093.1NP_001356022.1  activating signal cointegrator 1 complex subunit 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Related
      ENSP00000500488.1, ENST00000672774.1
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133356
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    13. NM_001369094.1NP_001356023.1  activating signal cointegrator 1 complex subunit 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133356
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    14. NM_001369095.1NP_001356024.1  activating signal cointegrator 1 complex subunit 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133356
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    15. NM_001369096.1NP_001356025.1  activating signal cointegrator 1 complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133313
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    16. NM_001369097.1NP_001356026.1  activating signal cointegrator 1 complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133313
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    17. NM_001369098.1NP_001356027.1  activating signal cointegrator 1 complex subunit 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133313
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    18. NM_001369099.1NP_001356028.1  activating signal cointegrator 1 complex subunit 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:84142
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:155338
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    19. NM_001369100.1NP_001356029.1  activating signal cointegrator 1 complex subunit 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133292
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    20. NM_001369101.1NP_001356030.1  activating signal cointegrator 1 complex subunit 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:2381
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:94293
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    21. NM_001369102.1NP_001356031.1  activating signal cointegrator 1 complex subunit 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Related
      ENSP00000431299.1, ENST00000486689.6
      Conserved Domains (2) summary
      cd02394
      Location:2381
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:94293
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    22. NM_001369103.1NP_001356032.1  activating signal cointegrator 1 complex subunit 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133292
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    23. NM_001369104.1NP_001356033.1  activating signal cointegrator 1 complex subunit 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133292
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    24. NM_001369105.1NP_001356034.1  activating signal cointegrator 1 complex subunit 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:2381
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:94317
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    25. NM_001369106.1NP_001356035.1  activating signal cointegrator 1 complex subunit 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:2381
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:94317
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    26. NM_001369107.1NP_001356036.1  activating signal cointegrator 1 complex subunit 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:2381
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:94317
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    27. NM_001369108.1NP_001356037.1  activating signal cointegrator 1 complex subunit 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Related
      ENSP00000500074.1, ENST00000672940.1
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133316
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    28. NM_001369109.1NP_001356038.1  activating signal cointegrator 1 complex subunit 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133316
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    29. NM_001369110.1NP_001356039.1  activating signal cointegrator 1 complex subunit 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133287
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    30. NM_001369111.1NP_001356040.1  activating signal cointegrator 1 complex subunit 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Related
      ENSP00000500906.1, ENST00000671788.1
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:133287
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    31. NM_001369112.1NP_001356041.1  activating signal cointegrator 1 complex subunit 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC022392, AL607035
      Related
      ENSP00000320810.7, ENST00000317168.11
      Conserved Domains (2) summary
      cd02394
      Location:62120
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      cl26521
      Location:133247
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RNA

    1. NR_045564.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5'-most exon and lacks three internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC022392, AK298302, CD706699, DC361917

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      72096032..72218777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448032.1XP_024303800.1  activating signal cointegrator 1 complex subunit 1 isoform X4

      Conserved Domains (2) summary
      cd02394
      Location:84142
      vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
      pfam10469
      Location:155335
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015947.3: Suppressed sequence

      Description
      NM_015947.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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