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    C1s1 complement component 1, s subcomponent 1 [ Mus musculus (house mouse) ]

    Gene ID: 50908, updated on 12-Aug-2019

    Summary

    Official Symbol
    C1s1provided by MGI
    Official Full Name
    complement component 1, s subcomponent 1provided by MGI
    Primary source
    MGI:MGI:1355312
    See related
    Ensembl:ENSMUSG00000038521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1s; C1sa; AA959438; AI255193; AI327365
    Expression
    Biased expression in bladder adult (RPKM 97.2), liver E18 (RPKM 57.1) and 14 other tissues See more

    Genomic context

    See C1s1 in Genome Data Viewer
    Location:
    6; 6 F2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124530344..124542392, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124480362..124492377, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115490373 Neighboring gene complement component 1, r subcomponent-like Neighboring gene complement component 1, r subcomponent A Neighboring gene complement component 1, r subcomponent A pseudogene Neighboring gene complement component 1, r subcomponent B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37773, MGC132830

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    complement C1s-A subcomponent
    Names
    C1 esterase
    complement component 1 subcomponent s-A
    complement component C1SA
    serine protease
    NP_001091086.1
    NP_659187.2
    XP_006506428.1
    XP_011239706.1
    XP_011239707.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097617.1NP_001091086.1  complement C1s-A subcomponent precursor

      See identical proteins and their annotated locations for NP_001091086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK087522, BB805732, BC111880, BY144429
      Consensus CDS
      CCDS51907.1
      UniProtKB/Swiss-Prot
      Q8CG14
      UniProtKB/TrEMBL
      E9Q6C2, Q14DT6
      Related
      ENSMUSP00000125712.1, ENSMUST00000162443.7
      Conserved Domains (6) summary
      cd00033
      Location:307361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443681
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:444684
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:181293
      CUB; CUB domain
      pfam14670
      Location:149177
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. NM_144938.2NP_659187.2  complement C1s-A subcomponent precursor

      See identical proteins and their annotated locations for NP_659187.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK087522, BB805732, BC111880, BY110216
      Consensus CDS
      CCDS51907.1
      UniProtKB/Swiss-Prot
      Q8CG14
      UniProtKB/TrEMBL
      E9Q6C2, Q14DT6
      Related
      ENSMUSP00000125531.1, ENSMUST00000160505.7
      Conserved Domains (6) summary
      cd00033
      Location:307361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443681
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:444684
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:181293
      CUB; CUB domain
      pfam14670
      Location:149177
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

      Range
      124530344..124542392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241405.2XP_011239707.1  complement C1s-A subcomponent isoform X2

      Conserved Domains (6) summary
      cd00033
      Location:283337
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:419657
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:2111
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:420660
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:125153
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00049
      Location:157269
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    2. XM_006506365.4XP_006506428.1  complement C1s-A subcomponent isoform X1

      See identical proteins and their annotated locations for XP_006506428.1

      UniProtKB/TrEMBL
      E9Q6C2
      Conserved Domains (6) summary
      cd00033
      Location:307361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443681
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:444684
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:181293
      CUB; CUB domain
      pfam14670
      Location:149177
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    3. XM_011241404.3XP_011239706.1  complement C1s-A subcomponent isoform X1

      See identical proteins and their annotated locations for XP_011239706.1

      UniProtKB/TrEMBL
      E9Q6C2
      Conserved Domains (6) summary
      cd00033
      Location:307361
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:443681
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:24135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:444684
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:181293
      CUB; CUB domain
      pfam14670
      Location:149177
      FXa_inhibition; Coagulation Factor Xa inhibitory site
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