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    COL18A1 collagen type XVIII alpha 1 chain [ Bos taurus (cattle) ]

    Gene ID: 508076, updated on 27-Aug-2018

    Summary

    Official Symbol
    COL18A1provided by VGNC
    Official Full Name
    collagen type XVIII alpha 1 chainprovided by VGNC
    Primary source
    VGNC:VGNC:27559
    See related
    Ensembl:ENSBTAG00000023907
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See COL18A1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 1 NC_037328.1 (145202124..145296602)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 1 AC_000158.1 (146989203..147041015)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene protein O-fucosyltransferase 2 Neighboring gene uncharacterized LOC112448009 Neighboring gene uncharacterized LOC101907800 Neighboring gene uncharacterized LOC112448014 Neighboring gene solute carrier family 19 member 1 Neighboring gene uncharacterized LOC100849587

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General protein information

    Preferred Names
    collagen alpha-1(XVIII) chain
    Names
    alpha 1 type XVIII collagen
    collagen, type XVIII, alpha 1
    procollagen, type XVIII, alpha 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083388.2NP_001076857.1  collagen alpha-1(XVIII) chain precursor

      See identical proteins and their annotated locations for NP_001076857.1

      Status: PROVISIONAL

      Source sequence(s)
      BC123531
      UniProtKB/TrEMBL
      A4FV05
      Related
      ENSBTAP00000034542.4, ENSBTAT00000034655.4
      Conserved Domains (4) summary
      pfam01391
      Location:810869
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:13371507
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:31196
      DUF959; Domain of Unknown Function (DUF959)
      cl22861
      Location:226415
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      145202124..145296602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024975155.1XP_024830923.1  collagen alpha-1(XVIII) chain isoform X5

      Conserved Domains (3) summary
      pfam01391
      Location:625684
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:11521322
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      cl22861
      Location:41230
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    2. XM_024975114.1XP_024830882.1  collagen alpha-1(XVIII) chain isoform X4

      Conserved Domains (4) summary
      pfam01391
      Location:810869
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:13461516
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:31196
      DUF959; Domain of Unknown Function (DUF959)
      cl22861
      Location:226415
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    3. XM_024975014.1XP_024830782.1  collagen alpha-1(XVIII) chain isoform X1

      Conserved Domains (5) summary
      pfam01391
      Location:10571116
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:15931763
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:31196
      DUF959; Domain of Unknown Function (DUF959)
      cl02447
      Location:348467
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      cl22861
      Location:473662
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    4. XM_024975043.1XP_024830811.1  collagen alpha-1(XVIII) chain isoform X2

      Conserved Domains (5) summary
      pfam01391
      Location:10571116
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:15851755
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:31196
      DUF959; Domain of Unknown Function (DUF959)
      cl02447
      Location:348467
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      cl22861
      Location:473662
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    5. XM_024975076.1XP_024830844.1  collagen alpha-1(XVIII) chain isoform X3

      Conserved Domains (5) summary
      pfam01391
      Location:10571116
      Collagen; Collagen triple helix repeat (20 copies)
      cd00247
      Location:15841754
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:31196
      DUF959; Domain of Unknown Function (DUF959)
      cl02447
      Location:348467
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
      cl22861
      Location:473662
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
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