Format

Send to:

Choose Destination
    • Showing Current items.

    Gne glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Mus musculus (house mouse) ]

    Gene ID: 50798, updated on 27-Jan-2018

    Summary

    Official Symbol
    Gneprovided by MGI
    Official Full Name
    glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinaseprovided by MGI
    Primary source
    MGI:MGI:1354951
    See related
    Ensembl:ENSMUSG00000028479 Vega:OTTMUSG00000007208
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NM; DMRV; IBM2; Uae1; GLCNE; 2310066H07Rik
    Expression
    Broad expression in colon adult (RPKM 40.8), genital fat pad adult (RPKM 9.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See Gne in Genome Data Viewer
    Location:
    4; 4 B1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (44034075..44084177, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (44046947..44097049, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene calicin Neighboring gene clathrin, light polypeptide (Lca) Neighboring gene prothymosin alpha pseudogene Neighboring gene ring finger protein 38 Neighboring gene microRNA 5106

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    N-acylmannosamine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    UDP-N-acetylglucosamine 2-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    N-acetylneuraminate metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    UDP-N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
    Names
    UDP-GlcNAc-2-epimerase/ManAc kinase
    UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
    NP_001177343.1
    NP_056643.3
    XP_006538136.1
    XP_006538137.1
    XP_017175799.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190414.2NP_001177343.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1

      See identical proteins and their annotated locations for NP_001177343.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains a different 5' terminal exon compared to transcript variant 1, which results in translation initiation from an in-frame downstream start codon. The resulting protein (isoform 1) has a shorter N-terminus compared to isoform 2. This variant has been called GNE1 in the scientific literature.
      Source sequence(s)
      AK033507, AK136573, AL732563, BB856323, BY036706, BY310771
      Consensus CDS
      CCDS51170.1
      UniProtKB/Swiss-Prot
      Q91WG8
      UniProtKB/TrEMBL
      Q3TCI8
      Related
      ENSMUSP00000100000.2, OTTMUSP00000007661, ENSMUST00000102936.8
      Conserved Domains (4) summary
      cd03786
      Location:11375
      GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
      COG1940
      Location:409722
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:11374
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
      cl17037
      Location:410669
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_001357539.1NP_001344468.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK033507, AK136573, AL732563, BB856323, BY036706, BY310771
      Conserved Domains (2) summary
      COG1940
      Location:205518
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      cl27436
      Location:8170
      Epimerase_2; UDP-N-acetylglucosamine 2-epimerase
    3. NM_015828.3NP_056643.3  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 2

      See identical proteins and their annotated locations for NP_056643.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest protein (isoform 2). This variant has been called GNE2 in the scientific literature.
      Source sequence(s)
      AK033507, AK136573, CF755618
      Consensus CDS
      CCDS18120.2
      UniProtKB/Swiss-Prot
      Q91WG8
      UniProtKB/TrEMBL
      Q3UW64
      Related
      ENSMUSP00000030201.7, OTTMUSP00000007660, ENSMUST00000030201.13, OTTMUST00000016636
      Conserved Domains (4) summary
      cd03786
      Location:42406
      GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
      COG1940
      Location:440753
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:42405
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
      cl17037
      Location:441700
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      44034075..44084177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538073.3XP_006538136.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1

      Conserved Domains (4) summary
      cd03786
      Location:36400
      GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
      COG1940
      Location:434747
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      TIGR03568
      Location:36399
      NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
      cl17037
      Location:435694
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. XM_017320310.1XP_017175799.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

      Conserved Domains (2) summary
      COG1940
      Location:205518
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      cl27436
      Location:8170
      Epimerase_2; UDP-N-acetylglucosamine 2-epimerase
    3. XM_006538074.3XP_006538137.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

      Conserved Domains (2) summary
      COG1940
      Location:350663
      NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
      cl27436
      Location:2315
      Epimerase_2; UDP-N-acetylglucosamine 2-epimerase
    Support Center