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    MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Bos taurus (cattle) ]

    Gene ID: 504592, updated on 27-Aug-2018

    Summary

    Official Symbol
    MAP3K2provided by VGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 2provided by VGNC
    Primary source
    VGNC:VGNC:31195
    See related
    BGD:BT13283; Ensembl:ENSBTAG00000004216
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See MAP3K2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 2 NC_037329.1 (5150438..5242682)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 2 AC_000159.1 (5083233..5174970)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene ras-related GTP-binding protein C pseudogene Neighboring gene protein C, inactivator of coagulation factors Va and VIIIa Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene uncharacterized LOC101904564 Neighboring gene microRNA 2285aa

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Gonadotropin-releasing hormone (GnRH) signaling, organism-specific biosystem (from WikiPathways)
      Gonadotropin-releasing hormone (GnRH) signaling, organism-specific biosystemGonadotropin-releasing hormones (GnRH) are the key factors stimulating gonadotropin release from the pituitary. GnRHs are decapeptides that act via G-protein coupled receptors (gonadotropin-releasing...
    • MAPK (ERK5) signaling, organism-specific biosystem (from KEGG)
      MAPK (ERK5) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (ERK5) signaling, conserved biosystem (from KEGG)
      MAPK (ERK5) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (JNK) signaling, organism-specific biosystem (from KEGG)
      MAPK (JNK) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (JNK) signaling, conserved biosystem (from KEGG)
      MAPK (JNK) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (p38) signaling, organism-specific biosystem (from KEGG)
      MAPK (p38) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK (p38) signaling, conserved biosystem (from KEGG)
      MAPK (p38) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

    General gene information

    Homology

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    XP_002685278.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      5150438..5242682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002685232.6XP_002685278.2  mitogen-activated protein kinase kinase kinase 2

      See identical proteins and their annotated locations for XP_002685278.2

      Related
      ENSBTAP00000005525.4
      Conserved Domains (2) summary
      cd06405
      Location:45123
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      cd06652
      Location:354617
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2
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