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    OPRL1 opioid related nociceptin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4987, updated on 17-Jun-2019

    Summary

    Official Symbol
    OPRL1provided by HGNC
    Official Full Name
    opioid related nociceptin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:8155
    See related
    Ensembl:ENSG00000125510 MIM:602548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOP; OOR; NOPr; ORL1; KOR-3; NOCIR
    Summary
    The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
    Expression
    Broad expression in brain (RPKM 1.7), testis (RPKM 0.9) and 14 other tissues See more
    Orthologs

    Genomic context

    See OPRL1 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (64080082..64100643)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62711451..62731996)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene SOX18 promoter region Neighboring gene transcription elongation factor A2 Neighboring gene SRY-box transcription factor 18 Neighboring gene regulator of G protein signaling 19 Neighboring gene microRNA 6813 Neighboring gene LKAAEAR motif containing 1 Neighboring gene neuropeptides B and W receptor 2 Neighboring gene B6.7 minisatellite repeat instability region

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC34578

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G protein-coupled receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nociceptin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nociceptin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein C-terminus binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    conditioned place preference IEA
    Inferred from Electronic Annotation
    more info
     
    eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    estrous cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    opioid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of locomotor rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception TAS
    Traceable Author Statement
    more info
    PubMed 
    sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nociceptin receptor
    Names
    kappa-type 3 opioid receptor
    kappa3-related opioid receptor
    nociceptin/orphanin FQ receptor
    opiate receptor-like 1
    orphanin FQ receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000913.6NP_000904.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_000904.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' non-coding region; therefore, has a shorter 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AF285093, BC038433, CB048300, R17579
      Consensus CDS
      CCDS13556.1
      UniProtKB/Swiss-Prot
      P41146
      Related
      ENSP00000347848.4, ENST00000355631.8
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001200019.2NP_001186948.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_001186948.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains alternate 5' non-coding exons; therefore, has a different 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AL590548, BC038433, CB048300, R17579
      Consensus CDS
      CCDS13556.1
      UniProtKB/Swiss-Prot
      P41146
      Related
      ENSP00000336764.3, ENST00000349451.3
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001318853.2NP_001305782.1  nociceptin receptor isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      AF285093, BC038433, CB048300, R17579
      UniProtKB/Swiss-Prot
      P41146
      Conserved Domains (2) summary
      pfam00001
      Location:68319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66188
      7tm_4; Olfactory receptor
    4. NM_001318854.1NP_001305783.1  nociceptin receptor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate, in-frame acceptor splice site in the 5' coding region compared to variant 1. The resulting isoform (2, also known as KOR-3D) is shorter, missing a 5 aa protein segment compared to isoform 1.
      Source sequence(s)
      AF126470, AL121581, BC038433, CB048300, R17579
      UniProtKB/Swiss-Prot
      P41146
      Conserved Domains (2) summary
      pfam00001
      Location:68314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66183
      7tm_4; Olfactory receptor
    5. NM_001318855.1NP_001305784.1  nociceptin receptor isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate acceptor splice site in the 5' coding region, which results in translation initiation from an alternate, downstream start codon compared to variant 1. The encoded isoform (3, also known as KOR-3A) is shorter, with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF115266, AL121581, BC038433, CB048300, R17579
      UniProtKB/Swiss-Prot
      P41146
      UniProtKB/TrEMBL
      Q8IXB0
      Conserved Domains (2) summary
      pfam00001
      Location:48290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:112159
      7tm_4; Olfactory receptor
    6. NM_182647.4NP_872588.1  nociceptin receptor isoform 1

      See identical proteins and their annotated locations for NP_872588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
      Source sequence(s)
      AF285093, BC038433, CB048300, R17579
      Consensus CDS
      CCDS13556.1
      UniProtKB/Swiss-Prot
      P41146
      Related
      ENSP00000336843.2, ENST00000336866.7
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      64080082..64100643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027854.1XP_016883343.1  nociceptin receptor isoform X2

      UniProtKB/Swiss-Prot
      P41146
      Conserved Domains (1) summary
      cd15092
      Location:52330
      7tmA_NOFQ_opioid_R; nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_017027853.1XP_016883342.1  nociceptin receptor isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:86337
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:84206
      7tm_4; Olfactory receptor
    3. XM_011528828.3XP_011527130.1  nociceptin receptor isoform X1

      Conserved Domains (2) summary
      pfam00001
      Location:86337
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:84206
      7tm_4; Olfactory receptor
    4. XM_011528830.3XP_011527132.1  nociceptin receptor isoform X4

      See identical proteins and their annotated locations for XP_011527132.1

      Conserved Domains (2) summary
      pfam00001
      Location:1238
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:60107
      7tm_4; Olfactory receptor
    5. XM_017027855.1XP_016883344.1  nociceptin receptor isoform X3

      UniProtKB/Swiss-Prot
      P41146
      Conserved Domains (2) summary
      pfam00001
      Location:68314
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:66183
      7tm_4; Olfactory receptor

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187624.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      2723..5589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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