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    Src64B Src oncogene at 64B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48973, updated on 9-Oct-2018

    Summary

    Official Symbol
    Src64Bprovided by FlyBase
    Official Full Name
    Src oncogene at 64Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262733
    Locus tag
    Dmel_CG7524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-src; C-src1; CG7524; D-src; D-Src64B; Dm SRC1; Dmel\CG7524; DmHD-358; dsrc; dSrc; Dsrc; DSrc; Dsrc64; DSrc64; DSRC64; Dsrc64B; DSrc64B; HD-358; MRE5; src; Src; SRC 64B; src1; Src1; src64; Src64; src64b; src64B; Src64b; SRC64B

    Genomic context

    See Src64B in Genome Data Viewer
    Location:
    64B11-64B12; 3-12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4592447..4626196, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4592447..4626196, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Histone deacetylase 1 Neighboring gene uncharacterized protein Neighboring gene axotactin

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of MAPKKK activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellularization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female germline ring canal formation, actin assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female germline ring canal stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    filtration diaphragm assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germarium-derived female germ-line cyst encapsulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of synaptic growth at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian fusome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian nurse cell to oocyte transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    parallel actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of torso signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of actin polymerization or depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol HDA PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    germline ring canal IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane HDA PubMed 

    General protein information

    Preferred Names
    Src oncogene at 64B
    Names
    CG7524-PB
    CG7524-PC
    CG7524-PD
    CG7524-PE
    CG7524-PF
    CG7524-PH
    CG7524-PI
    CG7524-PJ
    CG7524-PK
    Src proto oncogene sequence
    Src64B-PB
    Src64B-PC
    Src64B-PD
    Src64B-PE
    Src64B-PF
    Src64B-PH
    Src64B-PI
    Src64B-PJ
    Src64B-PK
    mRNA-like ncRNA in embryogenesis 5
    NP_001014561.1
    NP_001014562.1
    NP_001014563.1
    NP_001014564.1
    NP_001189051.1
    NP_001246628.1
    NP_001246629.1
    NP_001286937.1
    NP_524934.2

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4592447..4626196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259699.2NP_001246628.1  Src oncogene at 64B, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246628.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0293527, FBtr0304990
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    2. NM_001259700.2NP_001246629.1  Src oncogene at 64B, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246629.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0293526, FBtr0304989
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    3. NM_001300008.1NP_001286937.1  Src oncogene at 64B, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCI2
      Related
      FBpp0310444, FBtr0343995
      Conserved Domains (4) summary
      cd09933
      Location:158259
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:285537
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:289538
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    4. NM_001014561.2NP_001014561.1  Src oncogene at 64B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0099946, FBtr0100505
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    5. NM_001014562.3NP_001014562.1  Src oncogene at 64B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0099944, FBtr0100504
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    6. NM_001014564.3NP_001014564.1  Src oncogene at 64B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014564.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0099947, FBtr0100507
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    7. NM_080195.4NP_524934.2  Src oncogene at 64B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524934.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0073177, FBtr0073321
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    8. NM_001014563.3NP_001014563.1  Src oncogene at 64B, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0099948, FBtr0100508
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
    9. NM_001202122.1NP_001189051.1  Src oncogene at 64B, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      UniProtKB/TrEMBL
      M9MSK3
      Related
      FBpp0291750, FBtr0302594
      Conserved Domains (4) summary
      cd09933
      Location:158258
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      cd11845
      Location:99150
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      smart00221
      Location:284536
      STYKc; Protein kinase; unclassified specificity
      cd05034
      Location:288537
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
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