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    CLN8 CLN8 transmembrane ER and ERGIC protein [ Canis lupus familiaris (dog) ]

    Gene ID: 488558, updated on 1-Mar-2025
    Gene symbol
    CLN8
    Gene description
    CLN8 transmembrane ER and ERGIC protein
    See related
    Ensembl:ENSCAFG00845019093 RGD:12090590
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table
    See CLN8 in Genome Data Viewer
    Location:
    chromosome: 37
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (30888770..30912784)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (31632530..31649934)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (30752705..30770116)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (30804432..30821842)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (30743370..30760756)

    Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene elongation factor 1-alpha 1-like Neighboring gene E3 ubiquitin-protein ligase RING2-like

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. A mutation in the CLN8 gene in English Setter dogs with neuronal ceroid-lipofuscinosis. Katz ML, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629147
    2. The molecular genetic basis of the neuronal ceroid lipofuscinoses. Gardiner RM. Neurol Sci, 2000. PMID 11073223
    3. Characterization of candidate genes for neuronal ceroid lipofuscinosis in dog. Drögemüller C, et al. J Hered, 2005. PMID 15958790
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the CLN8 T-to-C transition is the likely cause of English Setter neuronal ceroid-lipofuscinosis
      Title: A mutation in the CLN8 gene in English Setter dogs with neuronal ceroid-lipofuscinosis.
    Submit: New GeneRIF Correction

    Homology

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in lipid homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    protein CLN8

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012343.1 → NP_001012343.1  protein CLN8

      See identical proteins and their annotated locations for NP_001012343.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ875419
      UniProtKB/Swiss-Prot
      Q2VUD9, Q5JZQ7
      UniProtKB/TrEMBL
      A0A8C0R8J9
      Related
      ENSCAFP00845026384.1, ENSCAFT00845033703.1
      Conserved Domains (1) summary
      smart00724
      Location:64 → 262
      TLC; TRAM, LAG1 and CLN8 homology domains

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051841.1 Reference ROS_Cfam_1.0

      Range
      30888770..30912784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038447323.1 → XP_038303251.1  protein CLN8 isoform X1

      UniProtKB/Swiss-Prot
      Q2VUD9, Q5JZQ7
      UniProtKB/TrEMBL
      A0A8C0R8J9
      Conserved Domains (1) summary
      smart00724
      Location:64 → 262
      TLC; TRAM, LAG1 and CLN8 homology domains

    2. XM_038447326.1 → XP_038303254.1  protein CLN8 isoform X1

      UniProtKB/Swiss-Prot
      Q2VUD9, Q5JZQ7
      UniProtKB/TrEMBL
      A0A8C0R8J9
      Conserved Domains (1) summary
      smart00724
      Location:64 → 262
      TLC; TRAM, LAG1 and CLN8 homology domains

    3. XM_038447324.1 → XP_038303252.1  protein CLN8 isoform X1

      UniProtKB/Swiss-Prot
      Q2VUD9, Q5JZQ7
      UniProtKB/TrEMBL
      A0A8C0R8J9
      Conserved Domains (1) summary
      smart00724
      Location:64 → 262
      TLC; TRAM, LAG1 and CLN8 homology domains

    4. XM_038447325.1 → XP_038303253.1  protein CLN8 isoform X1

      UniProtKB/Swiss-Prot
      Q2VUD9, Q5JZQ7
      UniProtKB/TrEMBL
      A0A8C0R8J9
      Conserved Domains (1) summary
      smart00724
      Location:64 → 262
      TLC; TRAM, LAG1 and CLN8 homology domains

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049297.1 Alternate UMICH_Zoey_3.1

      Range
      30804432..30821842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

      Range
      30743370..30760756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

      Range
      30752705..30770116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      31632530..31649934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JZQ7.1 GenPept UniProtKB/Swiss-Prot:Q5JZQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials