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    LYN LYN proto-oncogene, Src family tyrosine kinase [ Pan troglodytes (chimpanzee) ]

    Gene ID: 472771, updated on 21-May-2019

    Summary

    Official Symbol
    LYNprovided by VGNC
    Official Full Name
    LYN proto-oncogene, Src family tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:8181
    Locus tag
    CK820_G0032856
    See related
    Ensembl:ENSPTRG00000020263
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See LYN in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 8 NC_036887.1 (53841687..53977928)
    104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 8 NC_006475.4 (56878008..57021214)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 8 NC_006475.3 (53648324..53786404)

    Chromosome 8 - NC_036887.1Genomic Context describing neighboring genes Neighboring gene XK related 4 Neighboring gene myotubularin-related protein 5 pseudogene Neighboring gene transmembrane protein 68 Neighboring gene trimethylguanosine synthase 1 Neighboring gene small nucleolar RNA SNORA1 Neighboring gene small nucleolar RNA U54 Neighboring gene 26S proteasome regulatory subunit 10B pseudogene Neighboring gene ribosomal protein S20

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Platelet activation, organism-specific biosystem (from KEGG)
      Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    tyrosine-protein kinase Lyn
    Names
    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    XP_003311845.1
    XP_016814989.1
    XP_528143.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036887.1 Reference Clint_PTRv2 Primary Assembly

      Range
      53841687..53977928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016959500.2XP_016814989.1  tyrosine-protein kinase Lyn isoform X1

    2. XM_528143.4XP_528143.2  tyrosine-protein kinase Lyn isoform X2

      See identical proteins and their annotated locations for XP_528143.2

      UniProtKB/TrEMBL
      H2R453
      Related
      ENSPTRP00000046608.4, ENSPTRT00000044800.5
      Conserved Domains (3) summary
      cd10364
      Location:125225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
    3. XM_003311797.4XP_003311845.1  tyrosine-protein kinase Lyn isoform X3

      See identical proteins and their annotated locations for XP_003311845.1

      UniProtKB/TrEMBL
      K7AHF5
      Conserved Domains (3) summary
      cd10364
      Location:104204
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:46101
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:218489
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
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