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    NAP1L1 nucleosome assembly protein 1 like 1 [ Homo sapiens (human) ]

    Gene ID: 4673, updated on 5-Sep-2021

    Summary

    Official Symbol
    NAP1L1provided by HGNC
    Official Full Name
    nucleosome assembly protein 1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:7637
    See related
    Ensembl:ENSG00000187109 MIM:164060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRP; NAP1; NAP1L
    Summary
    This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 100.8), lymph node (RPKM 74.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NAP1L1 in Genome Data Viewer
    Location:
    12q21.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (76036585..76084687, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (76430365..76478465, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369847 Neighboring gene pleckstrin homology like domain family A member 1 Neighboring gene density regulated re-initiation and release factor pseudogene Neighboring gene RNA, U6 small nuclear 1271, pseudogene Neighboring gene reticulon 4 interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, nucleosome assembly protein 1-like 1 (NAP1L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NAP1L1 is decreased by RRE PubMed
    rev HIV-1 Rev interacts with nucleosome assembly protein 1 (Nap1) in cells and this interaction involves amino acid residues 41-51 in Rev. Nap1 modulates the nuclear import of Rev PubMed
    Tat tat NAP1 co-localizes with HIV-1 Tat at the nuclear rim and is required for the transport of Tat within the nucleus rather than for the remodeling of nucleosomes on the provirus PubMed
    tat HIV-1 Tat, NAP-1, and p300 synergistically activate HIV-1 transcription PubMed
    tat NAP-1 interacts with HIV-1 Tat, leading to cooperative activation of HIV-1 gene expression. Residues 162-391 of NAP-1 and residues 49-57 of Tat are involved in the interaction PubMed
    tat NAP1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed
    nucleocapsid gag Nucleosome assembly protein 1-like 1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC8688, FLJ16112, MGC23410

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of neural precursor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neurogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nucleosome assembly protein 1-like 1
    Names
    HSP22-like protein interacting protein
    NAP-1-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307924.3NP_001294853.1  nucleosome assembly protein 1-like 1 isoform 2

      See identical proteins and their annotated locations for NP_001294853.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two exons in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011611, AK295147, AL162068, BF666587, BM929581, BU183927, DA512918, HY300507
      Consensus CDS
      CCDS76581.1
      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      B7Z2V4, F5H4R6
      Related
      ENSP00000445008.2, ENST00000535020.6
      Conserved Domains (1) summary
      pfam00956
      Location:76344
      NAP; Nucleosome assembly protein (NAP)
    2. NM_001330231.2NP_001317160.1  nucleosome assembly protein 1-like 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, CX870413, DA137494, DA512918, DB546929, M86667
      Consensus CDS
      CCDS9013.1
      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      A0A024RBB7, Q9H2B0
      Conserved Domains (1) summary
      pfam00956
      Location:76343
      NAP; Nucleosome assembly protein (NAP)
    3. NM_001330232.2NP_001317161.1  nucleosome assembly protein 1-like 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the 5' coding region and differs in the 3' UTR compared to variant 2. The encoded isoform (3) is shorter, but has the same N- and C-termini as isoform 1.
      Source sequence(s)
      AA057019, AC011611, AF300335, AL162068, AW950481, CD000987, CD678271, DA137494, DA344092, DA512918, DB546929, M86667
      Consensus CDS
      CCDS81715.1
      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      F8W543, Q9H2B0
      Conserved Domains (1) summary
      pfam00956
      Location:13280
      NAP; Nucleosome assembly protein (NAP)
    4. NM_004537.7NP_004528.1  nucleosome assembly protein 1-like 1 isoform 1

      See identical proteins and their annotated locations for NP_004528.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, DA137494, DA512918, DB546929
      Consensus CDS
      CCDS9013.1
      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      A0A024RBB7, Q9H2B0
      Related
      ENSP00000477538.1, ENST00000618691.5
      Conserved Domains (1) summary
      pfam00956
      Location:76343
      NAP; Nucleosome assembly protein (NAP)
    5. NM_139207.5NP_631946.1  nucleosome assembly protein 1-like 1 isoform 1

      See identical proteins and their annotated locations for NP_631946.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 4 encode the same isoform (1).
      Source sequence(s)
      AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, DA137494, DA512918, DB546929, M86667
      Consensus CDS
      CCDS9013.1
      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      A0A024RBB7, Q9H2B0
      Related
      ENSP00000376947.3, ENST00000393263.7
      Conserved Domains (1) summary
      pfam00956
      Location:76343
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      76036585..76084687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019340.2XP_016874829.1  nucleosome assembly protein 1-like 1 isoform X2

      UniProtKB/TrEMBL
      F8W543
      Conserved Domains (1) summary
      pfam00956
      Location:13280
      NAP; Nucleosome assembly protein (NAP)
    2. XM_017019338.1XP_016874827.1  nucleosome assembly protein 1-like 1 isoform X1

      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      A0A024RBB7
      Related
      ENSP00000450236.1, ENST00000552056.5
      Conserved Domains (1) summary
      pfam00956
      Location:76343
      NAP; Nucleosome assembly protein (NAP)
    3. XM_024448983.1XP_024304751.1  nucleosome assembly protein 1-like 1 isoform X2

      Related
      ENSP00000448167.1, ENST00000547773.5
      Conserved Domains (1) summary
      pfam00956
      Location:13280
      NAP; Nucleosome assembly protein (NAP)
    4. XM_017019339.1XP_016874828.1  nucleosome assembly protein 1-like 1 isoform X2

      UniProtKB/TrEMBL
      F8W543
      Conserved Domains (1) summary
      pfam00956
      Location:13280
      NAP; Nucleosome assembly protein (NAP)
    5. XM_011538393.2XP_011536695.1  nucleosome assembly protein 1-like 1 isoform X1

      See identical proteins and their annotated locations for XP_011536695.1

      UniProtKB/Swiss-Prot
      P55209
      UniProtKB/TrEMBL
      A0A024RBB7
      Conserved Domains (1) summary
      pfam00956
      Location:76343
      NAP; Nucleosome assembly protein (NAP)

    RNA

    1. XR_001748717.2 RNA Sequence

    2. XR_001748715.2 RNA Sequence

    3. XR_001748714.2 RNA Sequence

    4. XR_001748716.1 RNA Sequence

    5. XR_002957328.1 RNA Sequence

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