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    CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 459660, updated on 3-Apr-2018

    Summary

    Official Symbol
    CACNB4provided by VGNC
    Official Full Name
    calcium voltage-gated channel auxiliary subunit beta 4provided by VGNC
    Primary source
    VGNC:VGNC:116
    See related
    Ensembl:ENSPTRG00000047916
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See CACNB4 in Genome Data Viewer
    Location:
    chromosome: 2B
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 2B NC_036881.1 (38403151..38667650, complement)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 2B NC_006470.3 (156033185..156300022, complement)

    Chromosome 2B - NC_036881.1Genomic Context describing neighboring genes Neighboring gene nebulin Neighboring gene ubiquitin-conjugating enzyme E2 C Neighboring gene ADP ribosylation factor like GTPase 5A Neighboring gene 60S ribosomal protein L30-like Neighboring gene uncharacterized LOC107973796 Neighboring gene signal transducing adaptor molecule 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
    • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
    • BioProject: PRJNA271912
    • Publication: PMID 25392405
    • Analysis date: Tue Apr 3 07:13:10 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    voltage-dependent L-type calcium channel subunit beta-4
    Names
    calcium channel, voltage-dependent, beta 4 subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036881.1 Reference Clint_PTRv2 Primary Assembly

      Range
      38403151..38667650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009443494.3XP_009441769.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X6

      Conserved Domains (3) summary
      cd12043
      Location:91158
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:5091
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl17190
      Location:230336
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    2. XM_009443491.3XP_009441766.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X4

      Related
      ENSPTRP00000084238.1
      Conserved Domains (2) summary
      cl17036
      Location:55115
      SH3; Src Homology 3 domain superfamily
      cl27059
      Location:177357
      Guanylate_kin; Guanylate kinase
    3. XM_003309288.5XP_003309336.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X1

      See identical proteins and their annotated locations for XP_003309336.1

      Related
      ENSPTRP00000056571.3
      Conserved Domains (3) summary
      cd12043
      Location:91158
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:5091
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:218398
      Guanylate_kin; Guanylate kinase
    4. XM_024354849.1XP_024210617.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X7

      Conserved Domains (3) summary
      cd12043
      Location:73140
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:3273
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:201317
      Guanylate_kin; Guanylate kinase
    5. XM_515833.5XP_515833.2  voltage-dependent L-type calcium channel subunit beta-4 isoform X2

      See identical proteins and their annotated locations for XP_515833.2

      UniProtKB/TrEMBL
      K7CXI1
      Related
      ENSPTRP00000088986.1
      Conserved Domains (3) summary
      cd12043
      Location:73140
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:3273
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:200380
      Guanylate_kin; Guanylate kinase
    6. XM_016949823.2XP_016805312.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X5

      Related
      ENSPTRP00000092268.1
      Conserved Domains (3) summary
      cd12043
      Location:44111
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:344
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:171351
      Guanylate_kin; Guanylate kinase
    7. XM_024354850.1XP_024210618.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X8

      Conserved Domains (3) summary
      cd12043
      Location:57124
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:1657
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:185301
      Guanylate_kin; Guanylate kinase
    8. XM_024354851.1XP_024210619.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X9

      Conserved Domains (3) summary
      cd12043
      Location:44111
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:344
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:172288
      Guanylate_kin; Guanylate kinase
    9. XM_001138599.4XP_001138599.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X3

      See identical proteins and their annotated locations for XP_001138599.1

      Related
      ENSPTRP00000091045.1, ENSPTRT00000084921.1
      Conserved Domains (3) summary
      cd12043
      Location:57124
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:1657
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:184364
      Guanylate_kin; Guanylate kinase
    10. XM_009443492.3XP_009441767.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X5

      See identical proteins and their annotated locations for XP_009441767.1

      Related
      ENSPTRP00000064808.1
      Conserved Domains (3) summary
      cd12043
      Location:44111
      SH3_CACNB4; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta4
      pfam12052
      Location:344
      VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
      cl27059
      Location:171351
      Guanylate_kin; Guanylate kinase
    11. XM_024354852.1XP_024210620.1  voltage-dependent L-type calcium channel subunit beta-4 isoform X10

      Conserved Domains (1) summary
      cl27059
      Location:1180
      Guanylate_kin; Guanylate kinase
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