Format

Send to:

Choose Destination
    • Showing Current items.

    MSH6 mutS homolog 6 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 459218, updated on 5-Oct-2018

    Summary

    Official Symbol
    MSH6provided by VGNC
    Official Full Name
    mutS homolog 6provided by VGNC
    Primary source
    VGNC:VGNC:301
    Locus tag
    CK820_G0028069
    See related
    Ensembl:ENSPTRG00000011906
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See MSH6 in Genome Data Viewer
    Location:
    chromosome: 2A
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 2A NC_036880.1 (47961917..47990418)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 2A NC_006469.3 (48544730..48570235)

    Chromosome 2A - NC_036880.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100614683 Neighboring gene uncharacterized protein C8orf59 homolog Neighboring gene F-box protein 11 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene uncharacterized LOC104004969

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
    • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
    • BioProject: PRJNA271912
    • Publication: PMID 25392405
    • Analysis date: Tue Apr 3 07:13:10 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BRCA1-associated genome surveillance complex (BASC), conserved biosystem (from KEGG)
      BRCA1-associated genome surveillance complex (BASC), conserved biosystemStructural complex; Genetic information processing; Repair system
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Mismatch repair, organism-specific biosystem (from KEGG)
      Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Mismatch repair, conserved biosystem (from KEGG)
      Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    DNA mismatch repair protein Msh6

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036880.1 Reference Clint_PTRv2 Primary Assembly

      Range
      47961917..47990418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009442435.3XP_009440710.3  DNA mismatch repair protein Msh6 isoform X1

      Conserved Domains (3) summary
      cd05837
      Location:88195
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG0249
      Location:4071336
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam14797
      Location:252350
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    2. XM_016948498.2XP_016803987.2  DNA mismatch repair protein Msh6 isoform X1

      Conserved Domains (3) summary
      cd05837
      Location:88195
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG0249
      Location:4071336
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam14797
      Location:252350
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    3. XM_024354340.1XP_024210108.1  DNA mismatch repair protein Msh6 isoform X2

      Conserved Domains (3) summary
      cd05837
      Location:27134
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG0249
      Location:3461275
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam14797
      Location:191289
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    4. XM_016948499.2XP_016803988.2  DNA mismatch repair protein Msh6 isoform X3

      Conserved Domains (3) summary
      cd05837
      Location:196
      MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
      COG0249
      Location:3081237
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam14797
      Location:153251
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    Support Center