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    ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Pan troglodytes (chimpanzee) ]

    Gene ID: 457552, updated on 5-Oct-2018

    Summary

    Official Symbol
    ABL2provided by VGNC
    Official Full Name
    ABL proto-oncogene 2, non-receptor tyrosine kinaseprovided by VGNC
    Primary source
    VGNC:VGNC:12980
    Locus tag
    CK820_G0013651
    See related
    Ensembl:ENSPTRG00000001727
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See ABL2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 1 NC_036879.1 (154216267..154346428, complement)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 1 NC_006468.3 (157602117..157736694, complement)

    Chromosome 1 - NC_036879.1Genomic Context describing neighboring genes Neighboring gene FAM20B, glycosaminoglycan xylosylkinase Neighboring gene torsin family 3 member A Neighboring gene protein SET-like Neighboring gene small nucleolar RNA SNORA67 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1-like Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene sterol O-acyltransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
    • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
    • BioProject: PRJNA271912
    • Publication: PMID 25392405
    • Analysis date: Tue Apr 3 07:13:10 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    Abelson tyrosine-protein kinase 2
    Names
    v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
    XP_009437332.1
    XP_009437339.1
    XP_009437349.1
    XP_009437354.1
    XP_009437355.1
    XP_009437360.1
    XP_009437363.1
    XP_009437370.1
    XP_016788833.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036879.1 Reference Clint_PTRv2 Primary Assembly

      Range
      154216267..154346428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009439088.3XP_009437363.1  Abelson tyrosine-protein kinase 2 isoform X7

      Conserved Domains (4) summary
      smart00808
      Location:9391058
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    2. XM_009439080.3XP_009437355.1  Abelson tyrosine-protein kinase 2 isoform X5

      UniProtKB/TrEMBL
      H2R8D7
      Related
      ENSPTRP00000051478.3
      Conserved Domains (4) summary
      smart00808
      Location:9601079
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    3. XM_009439057.3XP_009437332.1  Abelson tyrosine-protein kinase 2 isoform X1

      Related
      ENSPTRP00000093561.1
      Conserved Domains (4) summary
      smart00808
      Location:10631182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    4. XM_009439079.3XP_009437354.1  Abelson tyrosine-protein kinase 2 isoform X4

      Conserved Domains (5) summary
      smart00808
      Location:10271146
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:252503
      Pkinase_Tyr; Protein tyrosine kinase
    5. XM_009439095.3XP_009437370.1  Abelson tyrosine-protein kinase 2 isoform X8

      See identical proteins and their annotated locations for XP_009437370.1

      UniProtKB/TrEMBL
      K7CL85
      Related
      ENSPTRP00000092999.1
      Conserved Domains (4) summary
      smart00808
      Location:9241043
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    6. XM_009439085.3XP_009437360.1  Abelson tyrosine-protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_009437360.1

      UniProtKB/TrEMBL
      K7CUY5
      Conserved Domains (4) summary
      smart00808
      Location:9451064
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    7. XM_009439064.3XP_009437339.1  Abelson tyrosine-protein kinase 2 isoform X2

      Related
      ENSPTRP00000075992.1
      Conserved Domains (4) summary
      smart00808
      Location:10481167
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    8. XM_009439074.3XP_009437349.1  Abelson tyrosine-protein kinase 2 isoform X3

      Related
      ENSPTRP00000088575.1
      Conserved Domains (4) summary
      smart00808
      Location:10421161
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    9. XM_016933344.2XP_016788833.1  Abelson tyrosine-protein kinase 2 isoform X9

      Related
      ENSPTRP00000090718.1
      Conserved Domains (3) summary
      cd09935
      Location:148241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
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