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    NTRK1 neurotrophic receptor tyrosine kinase 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 457408, updated on 23-Mar-2018

    Summary

    Official Symbol
    NTRK1provided by VGNC
    Official Full Name
    neurotrophic receptor tyrosine kinase 1provided by VGNC
    Primary source
    VGNC:VGNC:9393
    See related
    Ensembl:ENSPTRG00000001478
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See NTRK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 1 NC_036879.1 (131643654..131683632)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 1 NC_006468.3 (135142776..135182974)

    Chromosome 1 - NC_036879.1Genomic Context describing neighboring genes Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene SH2 domain containing 2A Neighboring gene insulin receptor related receptor Neighboring gene platelet endothelial aggregation receptor 1 Neighboring gene leucine rich repeat containing 71

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
    • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
    • BioProject: PRJNA271912
    • Publication: PMID 25392405
    • Analysis date: Tue Apr 3 07:13:10 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
      Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
    • Central carbon metabolism in cancer, conserved biosystem (from KEGG)
      Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    high affinity nerve growth factor receptor
    Names
    neurotrophic tyrosine kinase, receptor, type 1
    XP_001145942.2
    XP_003308563.1
    XP_009432919.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036879.1 Reference Clint_PTRv2 Primary Assembly

      Range
      131643654..131683632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009434644.3XP_009432919.1  high affinity nerve growth factor receptor isoform X3

      Related
      ENSPTRP00000078223.1
      Conserved Domains (7) summary
      cd04971
      Location:245325
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:141228
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd05092
      Location:450729
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:3962
      LRR_1; leucine-rich repeat [structural motif]
      pfam07714
      Location:456727
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:3896
      LRR_8; Leucine rich repeat
      pfam16920
      Location:97138
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. XM_003308515.4XP_003308563.1  high affinity nerve growth factor receptor isoform X1

      Related
      ENSPTRP00000083380.1
      Conserved Domains (8) summary
      cd04971
      Location:325405
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:221308
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      pfam07679
      Location:224308
      I-set; Immunoglobulin I-set domain
      cd05092
      Location:530809
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:94118
      LRR_1; leucine-rich repeat [structural motif]
      pfam07714
      Location:536807
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:118176
      LRR_8; Leucine rich repeat
      pfam16920
      Location:177218
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. XM_001145942.5XP_001145942.2  high affinity nerve growth factor receptor isoform X2

      Related
      ENSPTRP00000040371.5
      Conserved Domains (8) summary
      cd04971
      Location:325405
      Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      cd04972
      Location:221308
      Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC
      pfam07679
      Location:224308
      I-set; Immunoglobulin I-set domain
      cd05092
      Location:524803
      PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A
      sd00031
      Location:94118
      LRR_1; leucine-rich repeat [structural motif]
      pfam07714
      Location:530801
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:118176
      LRR_8; Leucine rich repeat
      pfam16920
      Location:177218
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
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