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    LAMA1 laminin subunit alpha 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 455302, updated on 5-Oct-2018

    Summary

    Official Symbol
    LAMA1provided by VGNC
    Official Full Name
    laminin subunit alpha 1provided by VGNC
    Primary source
    VGNC:VGNC:5178
    Locus tag
    CK820_G0018419
    See related
    Ensembl:ENSPTRG00000009849
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs

    Genomic context

    See LAMA1 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    64
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) 18 NC_036897.1 (7822334..7997270)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 18 NC_006485.3 (9481112..9659630)

    Chromosome 18 - NC_036897.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene leucine rich repeat containing 30 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC107969439

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific RNA-sequencing for ten non-human primate species
    • Description: Total RNA sequencing of fifteen different tissues for ten non-human primates
    • BioProject: PRJNA271912
    • Publication: PMID 25392405
    • Analysis date: Tue Apr 3 07:13:10 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...

    General gene information

    Markers

    Homology

    General protein information

    Preferred Names
    laminin subunit alpha-1
    Names
    laminin, alpha 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Clint_PTRv2 Primary Assembly

    Genomic

    1. NC_036897.1 Reference Clint_PTRv2 Primary Assembly

      Range
      7822334..7997270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016933333.2XP_016788822.1  laminin subunit alpha-1 isoform X3

    2. XM_009433670.3XP_009431945.2  laminin subunit alpha-1 isoform X1

      Conserved Domains (10) summary
      smart00136
      Location:16268
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:12131344
      LamB; Laminin B domain
      smart00282
      Location:21412280
      LamG; Laminin G domain
      cd00055
      Location:848900
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:23072463
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:902948
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27532882
      Laminin_G_1; Laminin G domain
      pfam06009
      Location:20112145
      Laminin_II; Laminin Domain II
      pfam06008
      Location:15751830
      Laminin_I; Laminin Domain I
      cl25732
      Location:17202029
      SMC_N; RecF/RecN/SMC N terminal domain
    3. XM_001141549.5XP_001141549.2  laminin subunit alpha-1 isoform X2

      Related
      ENSPTRP00000016769.6
      Conserved Domains (10) summary
      smart00136
      Location:16268
      LamNT; Laminin N-terminal domain (domain VI)
      smart00281
      Location:12131344
      LamB; Laminin B domain
      smart00282
      Location:21412280
      LamG; Laminin G domain
      cd00055
      Location:848900
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:23072463
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:902948
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27432872
      Laminin_G_1; Laminin G domain
      pfam06009
      Location:20112145
      Laminin_II; Laminin Domain II
      pfam06008
      Location:15751830
      Laminin_I; Laminin Domain I
      cl25732
      Location:17202029
      SMC_N; RecF/RecN/SMC N terminal domain
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