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    MYD88 MYD88, innate immune signal transduction adaptor [ Bos taurus (cattle) ]

    Gene ID: 444881, updated on 17-Sep-2018

    Summary

    Official Symbol
    MYD88provided by VGNC
    Official Full Name
    MYD88, innate immune signal transduction adaptorprovided by VGNC
    Primary source
    VGNC:VGNC:31789
    See related
    BGD:BT10195; Ensembl:ENSBTAG00000000563
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See MYD88 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 22 NC_037349.1 (11609334..11613790)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 22 AC_000179.1 (11646548..11651004)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene DLEC1, cilia and flagella associated protein Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene oxidative stress responsive kinase 1 Neighboring gene solute carrier family 22 member 13

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    TIR domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    Toll-like receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    MyD88-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidised low-density lipoprotein particle stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
     
    induced systemic resistance IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of growth of symbiont in host IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chemokine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-17 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-23 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lymphocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of chemokine (C-X-C motif) ligand 1 production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of chemokine (C-X-C motif) ligand 2 production IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of neutrophil migration IEA
    Inferred from Electronic Annotation
    more info
     
    response to molecule of fungal origin IEA
    Inferred from Electronic Annotation
    more info
     
    response to peptidoglycan IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    type I interferon biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myeloid differentiation primary response protein MyD88
    Names
    myeloid differentiation factor 88
    myeloid differentiation primary response 88
    myeloid differentiation primary response gene (88)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014382.2NP_001014404.1  myeloid differentiation primary response protein MyD88

      See identical proteins and their annotated locations for NP_001014404.1

      Status: PROVISIONAL

      Source sequence(s)
      BC102851
      UniProtKB/Swiss-Prot
      Q599T9
      UniProtKB/TrEMBL
      A0A0P0QLG6
      Related
      ENSBTAP00000000735.3, ENSBTAT00000000735.3
      Conserved Domains (2) summary
      smart00255
      Location:160294
      TIR; Toll - interleukin 1 - resistance
      cd08312
      Location:29106
      Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      11609334..11613790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005222379.3XP_005222436.1  myeloid differentiation primary response protein MyD88 isoform X1

      Conserved Domains (1) summary
      cd08312
      Location:117194
      Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

    RNA

    1. XR_003031711.1 RNA Sequence

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