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    FeCH Ferrochelatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43757, updated on 8-Oct-2018

    Summary

    Official Symbol
    FeCHprovided by FlyBase
    Official Full Name
    Ferrochelataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266268
    Locus tag
    Dmel_CG2098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2098; Dmel\CG2098; ferrochelatase

    Genomic context

    See FeCH in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31810460..31812296, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27636182..27638018, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 100F Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene hephaestus Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    • Homologs of the FeCH gene: The FeCH gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ferrochelatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ferrochelatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ferrochelatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protoporphyrinogen IX biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ferrochelatase
    Names
    CG2098-PA
    CG2098-PB
    CG2098-PC
    FeCH-PA
    FeCH-PB
    FeCH-PC
    NP_524613.1
    NP_733458.1
    NP_733459.2

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31810460..31812296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079874.3NP_524613.1  ferrochelatase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524613.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9S8
      Related
      FBpp0085208, FBtr0085849
      Conserved Domains (3) summary
      cd00419
      Location:195332
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:29190
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:29349
      Ferrochelatase; Ferrochelatase
    2. NM_170579.3NP_733458.1  ferrochelatase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9S8
      Related
      FBpp0085209, FBtr0085850
      Conserved Domains (3) summary
      cd00419
      Location:195280
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:29190
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:29280
      Ferrochelatase; Ferrochelatase
    3. NM_170580.3NP_733459.2  ferrochelatase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733459.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V9S8
      Related
      FBpp0085210, FBtr0085851
      Conserved Domains (2) summary
      cd00419
      Location:37174
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:21191
      Ferrochelatase; Ferrochelatase
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