Format

Send to:

Choose Destination
    • Showing Current items.

    MLLT3 MLLT3 super elongation complex subunit [ Homo sapiens (human) ]

    Gene ID: 4300, updated on 15-Jun-2019

    Summary

    Official Symbol
    MLLT3provided by HGNC
    Official Full Name
    MLLT3 super elongation complex subunitprovided by HGNC
    Primary source
    HGNC:HGNC:7136
    See related
    Ensembl:ENSG00000171843 MIM:159558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AF9; YEATS3
    Expression
    Ubiquitous expression in thyroid (RPKM 6.2), colon (RPKM 4.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See MLLT3 in Genome Data Viewer
    Location:
    9p21.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (20341665..20622543, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (20341663..20622514, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 member 2 Neighboring gene glutaredoxin 3 pseudogene 1 Neighboring gene survival of motor neuron 1, telomeric pseudogene Neighboring gene RNA, U4 small nuclear 26, pseudogene Neighboring gene microRNA 4473 Neighboring gene uncharacterized LOC107987052 Neighboring gene microRNA 4474 Neighboring gene ribosomal protein L7a pseudogene 48 Neighboring gene FOCAD antisense RNA 1 Neighboring gene focadhesin Neighboring gene microRNA 491

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat forms at least two distinct P-TEFb-containing complexes. Tatcom1 is composed of P-TEFb, AF9, ENL, ELL, AFF1, AFF4, and PAF1, presenting strong CTD-kinase activity, while Tatcom2 consists of 7SK, LARP7, and MEPCE with two molecules of Tat/P-TEFb PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ2035, FLJ46355

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein AF-9
    Names
    ALL1-fused gene from chromosome 9 protein
    YEATS domain-containing protein 3
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
    myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein
    myeloid/lymphoid or mixed-lineage leukemia; translocated to 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286691.2NP_001273620.1  protein AF-9 isoform b

      See identical proteins and their annotated locations for NP_001273620.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK301474, AL512635, DC306929
      Consensus CDS
      CCDS69579.1
      UniProtKB/Swiss-Prot
      P42568
      Related
      ENSP00000485996.1, ENST00000630269.2
      Conserved Domains (1) summary
      pfam03366
      Location:26106
      YEATS; YEATS family
    2. NM_004529.4NP_004520.2  protein AF-9 isoform a

      See identical proteins and their annotated locations for NP_004520.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL512635, BC036089, L13744
      Consensus CDS
      CCDS6494.1
      UniProtKB/Swiss-Prot
      P42568
      UniProtKB/TrEMBL
      A0A0S2Z448
      Related
      ENSP00000369695.4, ENST00000380338.9
      Conserved Domains (1) summary
      pfam03366
      Location:29109
      YEATS; YEATS family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      20341669..20622499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014726.2XP_016870215.1  protein AF-9 isoform X1

    2. XM_017014727.1XP_016870216.1  protein AF-9 isoform X2

    Support Center