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    RAG2 recombination activating gene 2 [ Gallus gallus (chicken) ]

    Gene ID: 423165, updated on 12-Aug-2018

    Summary

    Official Symbol
    RAG2provided by CGNC
    Official Full Name
    recombination activating gene 2provided by CGNC
    Primary source
    CGNC:6005
    See related
    Ensembl:ENSGALG00000046408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    Rag-2
    Orthologs

    Genomic context

    See RAG2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 5 NC_006092.5 (19753281..20005084, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 5 NC_006092.4 (19519715..19524759, complement)

    Chromosome 5 - NC_006092.5Genomic Context describing neighboring genes Neighboring gene chromosome 5 C11orf74 homolog Neighboring gene TNF receptor associated factor 6 Neighboring gene recombination activating 1 Neighboring gene uncharacterized LOC107056418 Neighboring gene uncharacterized LOC101752331

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    methylated histone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-3,4,5-trisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-3,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    B cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell differentiation in thymus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    V(D)J recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    V(D)J recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    V(D)J recombination-activating protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305057.2NP_001291986.1  V(D)J recombination-activating protein 2

      See identical proteins and their annotated locations for NP_001291986.1

      Status: VALIDATED

      Source sequence(s)
      AADN04000062, CV889695
      UniProtKB/TrEMBL
      A0A1L1RM35
      Related
      ENSGALP00000059818.1, ENSGALT00000086146.1
      Conserved Domains (4) summary
      sd00038
      Location:144208
      Kelch; KELCH repeat [structural motif]
      pfam03089
      Location:58397
      RAG2; Recombination activating protein 2
      pfam13341
      Location:422499
      RAG2_PHD; RAG2 PHD domain
      pfam13415
      Location:99152
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006092.5 Reference GRCg6a Primary Assembly

      Range
      19753281..20005084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025150703.1XP_025006471.1  V(D)J recombination-activating protein 2 isoform X1

      Conserved Domains (3) summary
      sd00038
      Location:175239
      Kelch; KELCH repeat [structural motif]
      pfam03089
      Location:89428
      RAG2; Recombination activating protein 2
      pfam13341
      Location:453530
      RAG2_PHD; RAG2 PHD domain
    2. XM_025150704.1XP_025006472.1  V(D)J recombination-activating protein 2 isoform X1

      Conserved Domains (3) summary
      sd00038
      Location:175239
      Kelch; KELCH repeat [structural motif]
      pfam03089
      Location:89428
      RAG2; Recombination activating protein 2
      pfam13341
      Location:453530
      RAG2_PHD; RAG2 PHD domain
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