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    MBD1 methyl-CpG binding domain protein 1 [ Homo sapiens (human) ]

    Gene ID: 4152, updated on 12-Aug-2018

    Summary

    Official Symbol
    MBD1provided by HGNC
    Official Full Name
    methyl-CpG binding domain protein 1provided by HGNC
    Primary source
    HGNC:HGNC:6916
    See related
    Ensembl:ENSG00000141644 MIM:156535; Vega:OTTHUMG00000132669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RFT; PCM1; CXXC3
    Summary
    The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in testis (RPKM 18.8), bone marrow (RPKM 9.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See MBD1 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (50266882..50281774, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47793252..47808144, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 310, pseudogene Neighboring gene cilia and flagella associated protein 53 Neighboring gene CXXC finger protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 458

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyl-CpG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyl-CpG binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    methylation-dependent chromatin silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    methyl-CpG-binding domain protein 1
    Names
    CXXC-type zinc finger protein 3
    methyl-CpG binding domain protein 1 isoform PCM1
    protein containing methyl-CpG-binding domain 1
    the regulator of fibroblast growth factor 2 (FGF-2) transcription

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029505.1 RefSeqGene

      Range
      5001..19893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204136.1NP_001191065.1  methyl-CpG-binding domain protein 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a longer isoform (6) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225889, AK291519, AK302004, CD723822
      Consensus CDS
      CCDS59320.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000468785.1, OTTHUMP00000262941, ENST00000590208.5, OTTHUMT00000448756
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    2. NM_001204137.1NP_001191066.1  methyl-CpG-binding domain protein 1 isoform 7

      See identical proteins and their annotated locations for NP_001191066.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an additional in-frame coding exon, and has a different 3' UTR compared to variant 1. This results in a longer isoform (7, also known as RFT-A) with an extra protein segment not found in isoform 1. This isoform has been shown to repress FGF-2 expression at the transcriptional level, and may be involved in FGF-2-dependent tumor progression (PMID:10187827).
      Source sequence(s)
      AK291519, AK295401, AK302004, BP384783
      Consensus CDS
      CCDS56073.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654, B4DI41
      Related
      ENSP00000405268.2, OTTHUMP00000262869, ENST00000457839.6, OTTHUMT00000448759
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    3. NM_001204138.1NP_001191067.1  methyl-CpG-binding domain protein 1 isoform 8

      See identical proteins and their annotated locations for NP_001191067.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) is the same as variant 7, except uses an alternate acceptor splice site at one of the coding exons, resulting in an isoform (8, also known as RFT-Aprime) that is 1 aa shorter than isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
      Source sequence(s)
      AK291519, AK295401, AK302004, BP384783
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654, B4DI41
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    4. NM_001204139.1NP_001191068.1  methyl-CpG-binding domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001191068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) contains an alternate 3' terminal non-coding exon, thus has a different 3' UTR compared to variant 1. Variants 1 and 14 encode the same isoform (1).
      Source sequence(s)
      AK291519, AK302004, BC047353
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000372407.5, OTTHUMP00000262864, ENST00000382948.9, OTTHUMT00000448753
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    5. NM_001204140.1NP_001191069.1  methyl-CpG-binding domain protein 1 isoform 9

      See identical proteins and their annotated locations for NP_001191069.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) is the same as variant 7, except lacks an in-frame coding exon, resulting in an isoform (9, also known as RFT-B) that is missing an internal protein segment compared to isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
      Source sequence(s)
      AK291519, AK295401, AK302004, BP384783
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654, B4DI41
      Related
      ENSP00000381508.2, OTTHUMP00000262943, ENST00000398495.6, OTTHUMT00000448882
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    6. NM_001204141.1NP_001191070.1  methyl-CpG-binding domain protein 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks 2 non-consecutive coding exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (10) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK225889, AK291519, AK302004, BC047353
      Consensus CDS
      CCDS59318.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000466092.1, OTTHUMP00000262939, ENST00000585672.5, OTTHUMT00000448751
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:281327
      zf-CXXC; CXXC zinc finger domain
    7. NM_001204142.1NP_001191071.1  methyl-CpG-binding domain protein 1 isoform 11

      See identical proteins and their annotated locations for NP_001191071.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks 3 non-consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (11) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF078831, AJ564845, AK291519, CD723822
      Consensus CDS
      CCDS56072.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000339546.5, OTTHUMP00000262865, ENST00000339998.10, OTTHUMT00000448755
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    8. NM_001204143.1NP_001191072.1  methyl-CpG-binding domain protein 1 isoform 12

      See identical proteins and their annotated locations for NP_001191072.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks 3 non-consecutive coding exons, and uses an alternate donor splice site at the 5' non-coding exon and an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (12) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF078831, AJ564845, AK300759, CD723822
      Consensus CDS
      CCDS59319.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      UniProtKB/TrEMBL
      B4DUR3
      Related
      ENSP00000468042.1, OTTHUMP00000262867, ENST00000587605.5, OTTHUMT00000448757
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    9. NM_001204151.2NP_001191080.1  methyl-CpG-binding domain protein 1 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks 2 non-consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (13) missing two internal protein segments compared to isoform 1.
      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS56071.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000465923.1, OTTHUMP00000262870, ENST00000591535.5, OTTHUMT00000448760
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:308354
      zf-CXXC; CXXC zinc finger domain
    10. NM_001323942.1NP_001310871.1  methyl-CpG-binding domain protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    11. NM_001323947.1NP_001310876.1  methyl-CpG-binding domain protein 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    12. NM_001323949.1NP_001310878.1  methyl-CpG-binding domain protein 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC090246
    13. NM_001323950.1NP_001310879.1  methyl-CpG-binding domain protein 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC090246
    14. NM_001323951.1NP_001310880.1  methyl-CpG-binding domain protein 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC090246
    15. NM_001323952.1NP_001310881.1  methyl-CpG-binding domain protein 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC090246
    16. NM_001323953.1NP_001310882.1  methyl-CpG-binding domain protein 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC090246
    17. NM_001323954.1NP_001310883.1  methyl-CpG-binding domain protein 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    18. NM_002384.2NP_002375.1  methyl-CpG-binding domain protein 1 isoform 4

      See identical proteins and their annotated locations for NP_002375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks 2 in-frame non-consecutive coding exons compared to variant 1, resulting in a shorter isoform (4) missing two internal protein segments compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225948, BC033242, DB458244, DC403953
      Consensus CDS
      CCDS11941.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000381502.1, OTTHUMP00000163506, ENST00000398488.5, OTTHUMT00000255925
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    19. NM_015844.2NP_056669.2  methyl-CpG-binding domain protein 1 isoform 3

      See identical proteins and their annotated locations for NP_056669.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225948, BC033242, DB458244, DC403953
      Consensus CDS
      CCDS11942.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000285102.5, ENST00000347968.7
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    20. NM_015845.3NP_056670.2  methyl-CpG-binding domain protein 1 isoform 2

      See identical proteins and their annotated locations for NP_056670.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing 3 non-consecutive coding exons compared to variant 1, the last of which causes a frame-shift. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
      Consensus CDS
      CCDS32832.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000269471.5, ENST00000269471.9
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:308354
      zf-CXXC; CXXC zinc finger domain
    21. NM_015846.3NP_056671.2  methyl-CpG-binding domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056671.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 14 encode the same isoform.
      Source sequence(s)
      AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000269468.5, ENST00000269468.9
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    22. NM_015847.3NP_056723.2  methyl-CpG-binding domain protein 1 isoform 5

      See identical proteins and their annotated locations for NP_056723.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (5) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225889, AK225948, BC033242, DB458244, DC403953
      Consensus CDS
      CCDS11944.1
      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000269469.5, OTTHUMP00000163505, ENST00000353909.7, OTTHUMT00000255924
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:282328
      zf-CXXC; CXXC zinc finger domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

      Range
      50266882..50281774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025775.2XP_016881264.1  methyl-CpG-binding domain protein 1 isoform X30

    2. XM_017025772.2XP_016881261.1  methyl-CpG-binding domain protein 1 isoform X27

    3. XM_017025768.2XP_016881257.1  methyl-CpG-binding domain protein 1 isoform X23

    4. XM_017025777.2XP_016881266.1  methyl-CpG-binding domain protein 1 isoform X33

    5. XM_017025755.2XP_016881244.1  methyl-CpG-binding domain protein 1 isoform X11

    6. XM_024451182.1XP_024306950.1  methyl-CpG-binding domain protein 1 isoform X28

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    7. XM_024451179.1XP_024306947.1  methyl-CpG-binding domain protein 1 isoform X19

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    8. XM_017025761.2XP_016881250.1  methyl-CpG-binding domain protein 1 isoform X18

    9. XM_017025754.2XP_016881243.1  methyl-CpG-binding domain protein 1 isoform X9

    10. XM_024451175.1XP_024306943.1  methyl-CpG-binding domain protein 1 isoform X3

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    11. XM_011526006.2XP_011524308.1  methyl-CpG-binding domain protein 1 isoform X29

      See identical proteins and their annotated locations for XP_011524308.1

      UniProtKB/Swiss-Prot
      Q9UIS9
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    12. XM_017025776.2XP_016881265.1  methyl-CpG-binding domain protein 1 isoform X31

      UniProtKB/Swiss-Prot
      Q9UIS9
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    13. XM_017025765.2XP_016881254.1  methyl-CpG-binding domain protein 1 isoform X21

    14. XM_011526001.2XP_011524303.1  methyl-CpG-binding domain protein 1 isoform X17

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    15. XM_017025770.2XP_016881259.1  methyl-CpG-binding domain protein 1 isoform X26

      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000381506.1, OTTHUMP00000163504, ENST00000398493.5
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    16. XM_011525999.2XP_011524301.1  methyl-CpG-binding domain protein 1 isoform X14

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    17. XM_017025769.2XP_016881258.1  methyl-CpG-binding domain protein 1 isoform X24

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    18. XM_011526007.2XP_011524309.1  methyl-CpG-binding domain protein 1 isoform X24

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    19. XM_017025752.2XP_016881241.1  methyl-CpG-binding domain protein 1 isoform X4

    20. XM_017025753.2XP_016881242.1  methyl-CpG-binding domain protein 1 isoform X5

    21. XM_017025760.2XP_016881249.1  methyl-CpG-binding domain protein 1 isoform X16

      UniProtKB/Swiss-Prot
      Q9UIS9
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    22. XM_005258271.3XP_005258328.1  methyl-CpG-binding domain protein 1 isoform X16

      See identical proteins and their annotated locations for XP_005258328.1

      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000467017.1, OTTHUMP00000163507, ENST00000591416.5
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331377
      zf-CXXC; CXXC zinc finger domain
    23. XM_024451181.1XP_024306949.1  methyl-CpG-binding domain protein 1 isoform X25

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    24. XM_024451180.1XP_024306948.1  methyl-CpG-binding domain protein 1 isoform X25

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    25. XM_024451178.1XP_024306946.1  methyl-CpG-binding domain protein 1 isoform X15

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    26. XM_024451177.1XP_024306945.1  methyl-CpG-binding domain protein 1 isoform X10

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    27. XM_017025767.2XP_016881256.1  methyl-CpG-binding domain protein 1 isoform X22

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    28. XM_017025766.2XP_016881255.1  methyl-CpG-binding domain protein 1 isoform X22

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168215
      zf-CXXC; CXXC zinc finger domain
    29. XM_024451176.1XP_024306944.1  methyl-CpG-binding domain protein 1 isoform X8

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:355401
      zf-CXXC; CXXC zinc finger domain
    30. XM_017025756.2XP_016881245.1  methyl-CpG-binding domain protein 1 isoform X12

    31. XM_011525991.2XP_011524293.1  methyl-CpG-binding domain protein 1 isoform X6

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    32. XM_017025764.2XP_016881253.1  methyl-CpG-binding domain protein 1 isoform X20

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    33. XM_011526003.3XP_011524305.1  methyl-CpG-binding domain protein 1 isoform X20

      See identical proteins and their annotated locations for XP_011524305.1

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    34. XM_011526002.2XP_011524304.1  methyl-CpG-binding domain protein 1 isoform X20

      See identical proteins and their annotated locations for XP_011524304.1

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    35. XM_017025751.2XP_016881240.1  methyl-CpG-binding domain protein 1 isoform X2

    36. XM_017025759.2XP_016881248.1  methyl-CpG-binding domain protein 1 isoform X13

    37. XM_017025758.2XP_016881247.1  methyl-CpG-binding domain protein 1 isoform X13

    38. XM_017025757.2XP_016881246.1  methyl-CpG-binding domain protein 1 isoform X13

    39. XM_006722456.3XP_006722519.1  methyl-CpG-binding domain protein 1 isoform X1

      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    40. XM_011525993.3XP_011524295.1  methyl-CpG-binding domain protein 1 isoform X7

      See identical proteins and their annotated locations for XP_011524295.1

      UniProtKB/Swiss-Prot
      Q9UIS9
      Related
      ENSP00000468430.1, OTTHUMP00000262868, ENST00000585595.5
      Conserved Domains (2) summary
      smart00391
      Location:376
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356402
      zf-CXXC; CXXC zinc finger domain
    41. XM_024451183.1XP_024306951.1  methyl-CpG-binding domain protein 1 isoform X32

      Conserved Domains (1) summary
      pfam02008
      Location:146
      zf-CXXC; CXXC zinc finger domain
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