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    THBS2 thrombospondin 2 [ Gallus gallus (chicken) ]

    Gene ID: 414837, updated on 2-Oct-2018

    Summary

    Symbol
    THBS2provided by CGNC
    Full Name
    thrombospondin 2provided by CGNC
    Primary source
    CGNC:49928
    See related
    Ensembl:ENSGALG00000011200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    thrombospondin-2
    Orthologs

    Genomic context

    See THBS2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 3 NC_006090.5 (41432031..41466039)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 3 NC_006090.4 (41483007..41517016)

    Chromosome 3 - NC_006090.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053043 Neighboring gene uncharacterized LOC101752128 Neighboring gene uncharacterized LOC112532098 Neighboring gene uncharacterized LOC107053042

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • ECM-receptor interaction, organism-specific biosystem (from KEGG)
      ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • ECM-receptor interaction, conserved biosystem (from KEGG)
      ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    platelet alpha granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001755.1NP_001001755.1  thrombospondin-2 precursor

      See identical proteins and their annotated locations for NP_001001755.1

      Status: PROVISIONAL

      Source sequence(s)
      M60853
      UniProtKB/Swiss-Prot
      P35440
      Conserved Domains (10) summary
      smart00209
      Location:503555
      TSP1; Thrombospondin type 1 repeats
      sd00001
      Location:853890
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:795829
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:699734
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:391436
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:326380
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:854890
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:9801177
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:658697
      EGF_3; EGF domain
      cl22861
      Location:33221
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006090.5 Reference GRCg6a Primary Assembly

      Range
      41432031..41466039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015284053.1XP_015139539.1  thrombospondin-2 isoform X2

      UniProtKB/Swiss-Prot
      P35440
      Conserved Domains (10) summary
      smart00209
      Location:503555
      TSP1; Thrombospondin type 1 repeats
      sd00001
      Location:853890
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:795829
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:699734
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:391436
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:326380
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:854890
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:9801177
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:658697
      EGF_3; EGF domain
      cl22861
      Location:33221
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    2. XM_015284051.2XP_015139537.1  thrombospondin-2 isoform X1

      UniProtKB/TrEMBL
      E1C3P2
      Related
      ENSGALP00000018239.4
      Conserved Domains (10) summary
      smart00209
      Location:538590
      TSP1; Thrombospondin type 1 repeats
      sd00001
      Location:888925
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:830864
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:734769
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam00090
      Location:426471
      TSP_1; Thrombospondin type 1 domain
      pfam00093
      Location:361415
      VWC; von Willebrand factor type C domain
      pfam02412
      Location:889925
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:10151212
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:693732
      EGF_3; EGF domain
      cl22861
      Location:68256
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
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