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    lck LCK proto-oncogene, Src family tyrosine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 414333, updated on 30-Sep-2018

    Summary

    Official Symbol
    lckprovided by ZNC
    Official Full Name
    LCK proto-oncogene, Src family tyrosine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040617-1
    See related
    Ensembl:ENSDARG00000102525 Vega:OTTDARG00000034081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:136695
    Annotation information
    Annotation category: partial on reference assembly

    Genomic context

    See lck in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25344736..25382420, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25326345..25364029, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 4 (inducible form) Neighboring gene transmembrane protein 54a Neighboring gene zona pellucida protein C Neighboring gene uncharacterized LOC110438042 Neighboring gene family with sequence similarity 167, member B Neighboring gene zgc:154055

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC136695, MGC194004, MGC194043

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase Lck
    Names
    lymphocyte protein tyrosine kinase
    lymphocyte-specific protein tyrosine kinase
    NP_001001596.1
    NP_001035418.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001596.1NP_001001596.1  tyrosine-protein kinase Lck isoform 1

      See identical proteins and their annotated locations for NP_001001596.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the isoform (1).
      Source sequence(s)
      AY390224
      UniProtKB/TrEMBL
      Q6TPQ4
      Related
      ENSDARP00000131919.1, OTTDARP00000037748, ENSDART00000162306.2, OTTDART00000048106
      Conserved Domains (4) summary
      cd10362
      Location:116216
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:57111
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:230493
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
      pfam07714
      Location:238487
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_001040328.1NP_001035418.1  tyrosine-protein kinase Lck isoform 2

      See identical proteins and their annotated locations for NP_001035418.1

      Status: PROVISIONAL

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is the same length but differs from isoform 1.
      Source sequence(s)
      BC115230
      UniProtKB/TrEMBL
      Q1RLY5
      Related
      ENSDARP00000130859.1, OTTDARP00000037747, ENSDART00000165282.2, OTTDART00000048105
      Conserved Domains (4) summary
      cd10362
      Location:116216
      SH2_Src_Lck; Src homology 2 (SH2) domain in lymphocyte cell kinase (Lck)
      cd12005
      Location:57111
      SH3_Lck; Src homology 3 domain of Lck Protein Tyrosine Kinase
      cd05067
      Location:230493
      PTKc_Lck_Blk; Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk
      pfam07714
      Location:238487
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      25344736..25382420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394991.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      271515..309199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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