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    MAP4 microtubule associated protein 4 [ Homo sapiens (human) ]

    Gene ID: 4134, updated on 12-Oct-2019

    Summary

    Official Symbol
    MAP4provided by HGNC
    Official Full Name
    microtubule associated protein 4provided by HGNC
    Primary source
    HGNC:HGNC:6862
    See related
    Ensembl:ENSG00000047849 MIM:157132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
    Expression
    Ubiquitous expression in heart (RPKM 53.7), brain (RPKM 28.3) and 23 other tissues See more
    Orthologs

    Genomic context

    See MAP4 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (47850695..48089272, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (47892180..48130769, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 Neighboring gene Sharpr-MPRA regulatory region 56 Neighboring gene DExH-box helicase 30 Neighboring gene microRNA 1226 Neighboring gene VPS26B pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 664, pseudogene Neighboring gene ribosomal protein L17 pseudogene 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of DNAL1 and MAP4 by siRNAs and shRNAs inhibits HIV-1 replication in HeLa P4.2 cells by blocking reverse transcription and 2-LTR formation PubMed
    Knockdown of microtubule-associated protein 4 (MAP4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated microtubule-associated protein 4 (MAP4) is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with microtubule-associated protein 4 (MAP4) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC8617, DKFZp779A1753

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    establishment of spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule sliding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    microtubule-associated protein 4
    Names
    MAP-4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052840.1 RefSeqGene

      Range
      5432..243585
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134364.2NP_001127836.1  microtubule-associated protein 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA904866, AB209377, DA114613
      Consensus CDS
      CCDS46818.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000379083.3, ENST00000395734.7
      Conserved Domains (1) summary
      pfam00418
      Location:9921021
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    2. NM_002375.5NP_002366.2  microtubule-associated protein 4 isoform 1

      See identical proteins and their annotated locations for NP_002366.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the longest isoform (1).
      Source sequence(s)
      AA904866, AB209377, DA114613, M64571
      Consensus CDS
      CCDS33750.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000353375.6, ENST00000360240.10
      Conserved Domains (1) summary
      pfam00418
      Location:9921021
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    3. NM_030885.4NP_112147.2  microtubule-associated protein 4 isoform 3

      See identical proteins and their annotated locations for NP_112147.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple exons in the 3' region and uses an unique splice site at the 3' end-exon compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA206810, AI078534, BC051843, DA114613, DA150735
      Consensus CDS
      CCDS46821.1
      UniProtKB/Swiss-Prot
      P27816
      Related
      ENSP00000397414.1, ENST00000439356.2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      47850695..48089272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006412.1XP_016861901.1  microtubule-associated protein 4 isoform X29

    2. XM_017006411.1XP_016861900.1  microtubule-associated protein 4 isoform X28

    3. XM_017006415.1XP_016861904.1  microtubule-associated protein 4 isoform X32

    4. XM_017006405.1XP_016861894.1  microtubule-associated protein 4 isoform X24

    5. XM_017006413.1XP_016861902.1  microtubule-associated protein 4 isoform X30

    6. XM_017006402.1XP_016861891.1  microtubule-associated protein 4 isoform X23

    7. XM_024453530.1XP_024309298.1  microtubule-associated protein 4 isoform X21

      Conserved Domains (2) summary
      pfam00418
      Location:10001029
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:552896
      Atrophin-1; Atrophin-1 family
    8. XM_017006416.1XP_016861905.1  microtubule-associated protein 4 isoform X33

    9. XM_017006401.1XP_016861890.1  microtubule-associated protein 4 isoform X22

    10. XM_024453529.1XP_024309297.1  microtubule-associated protein 4 isoform X17

      Conserved Domains (2) summary
      pfam00418
      Location:10401069
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl26464
      Location:592936
      Atrophin-1; Atrophin-1 family
    11. XM_017006397.1XP_016861886.1  microtubule-associated protein 4 isoform X19

    12. XM_017006395.1XP_016861884.1  microtubule-associated protein 4 isoform X16

    13. XM_011533719.2XP_011532021.1  microtubule-associated protein 4 isoform X15

      Conserved Domains (1) summary
      pfam00418
      Location:10211050
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    14. XM_011533708.2XP_011532010.1  microtubule-associated protein 4 isoform X7

      Conserved Domains (1) summary
      pfam00418
      Location:21342163
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    15. XM_011533718.1XP_011532020.1  microtubule-associated protein 4 isoform X14

      Conserved Domains (2) summary
      pfam05086
      Location:19942152
      Dicty_REP; Dictyostelium (Slime Mold) REP protein
      pfam00418
      Location:21112140
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    16. XM_011533705.1XP_011532007.1  microtubule-associated protein 4 isoform X5

      Related
      ENSP00000407602.2, ENST00000426837.6
      Conserved Domains (1) summary
      pfam00418
      Location:21492178
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    17. XM_024453528.1XP_024309296.1  microtubule-associated protein 4 isoform X13

      Conserved Domains (3) summary
      pfam00418
      Location:21252154
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:18422021
      Atrophin-1; Atrophin-1 family
    18. XM_024453527.1XP_024309295.1  microtubule-associated protein 4 isoform X12

      Conserved Domains (3) summary
      pfam00418
      Location:21252154
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:18422021
      Atrophin-1; Atrophin-1 family
    19. XM_024453526.1XP_024309294.1  microtubule-associated protein 4 isoform X11

      Conserved Domains (3) summary
      pfam00418
      Location:21512180
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:18432132
      Atrophin-1; Atrophin-1 family
    20. XM_017006391.1XP_016861880.1  microtubule-associated protein 4 isoform X4

    21. XM_011533704.2XP_011532006.1  microtubule-associated protein 4 isoform X3

      Conserved Domains (1) summary
      pfam00418
      Location:21512180
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    22. XM_017006392.1XP_016861881.1  microtubule-associated protein 4 isoform X10

    23. XM_011533709.2XP_011532011.1  microtubule-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam00418
      Location:21282157
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    24. XM_024453525.1XP_024309293.1  microtubule-associated protein 4 isoform X8

      Conserved Domains (3) summary
      pfam00418
      Location:21662195
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:18442093
      Atrophin-1; Atrophin-1 family
    25. XM_024453524.1XP_024309292.1  microtubule-associated protein 4 isoform X6

      Conserved Domains (3) summary
      pfam00418
      Location:21662195
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:18442093
      Atrophin-1; Atrophin-1 family
    26. XM_011533703.2XP_011532005.1  microtubule-associated protein 4 isoform X2

      Conserved Domains (1) summary
      pfam00418
      Location:21662195
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    27. XM_024453523.1XP_024309291.1  microtubule-associated protein 4 isoform X1

      Conserved Domains (3) summary
      pfam00418
      Location:21972226
      Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
      cl00062
      Location:93260
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl26464
      Location:18442093
      Atrophin-1; Atrophin-1 family
    28. XM_017006414.1XP_016861903.1  microtubule-associated protein 4 isoform X31

    29. XM_017006409.2XP_016861898.1  microtubule-associated protein 4 isoform X26

    30. XM_017006410.2XP_016861899.1  microtubule-associated protein 4 isoform X27

    31. XM_017006406.2XP_016861895.1  microtubule-associated protein 4 isoform X25

    32. XM_017006400.2XP_016861889.1  microtubule-associated protein 4 isoform X20

    33. XM_017006396.2XP_016861885.1  microtubule-associated protein 4 isoform X18

    RNA

    1. XR_002959533.1 RNA Sequence

    2. XR_002959534.1 RNA Sequence

    3. XR_002959532.1 RNA Sequence

    4. XR_002959526.1 RNA Sequence

    5. XR_002959528.1 RNA Sequence

    6. XR_002959524.1 RNA Sequence

    7. XR_002959530.1 RNA Sequence

    8. XR_002959522.1 RNA Sequence

    9. XR_002959520.1 RNA Sequence

    10. XR_002959527.1 RNA Sequence

    11. XR_002959523.1 RNA Sequence

    12. XR_002959525.1 RNA Sequence

    13. XR_002959521.1 RNA Sequence

    14. XR_002959531.1 RNA Sequence

    15. XR_002959529.1 RNA Sequence

    16. XR_002959519.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001134365.1: Suppressed sequence

      Description
      NM_001134365.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_030884.3: Suppressed sequence

      Description
      NM_030884.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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