Format

Send to:

Choose Destination
    • Showing Current items.

    FAM19A1 family with sequence similarity 19 member A1, C-C motif chemokine like [ Homo sapiens (human) ]

    Gene ID: 407738, updated on 5-Aug-2018

    Summary

    Official Symbol
    FAM19A1provided by HGNC
    Official Full Name
    family with sequence similarity 19 member A1, C-C motif chemokine likeprovided by HGNC
    Primary source
    HGNC:HGNC:21587
    See related
    Ensembl:ENSG00000183662 MIM:617495; Vega:OTTHUMG00000158745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAFA1; TAFA-1
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 6.6) and prostate (RPKM 0.3) See more
    Orthologs

    Genomic context

    See FAM19A1 in Genome Data Viewer
    Location:
    3p14.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (67991592..68546056)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (68040734..68594772)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene succinate-CoA ligase GDP-forming beta subunit Neighboring gene uncharacterized LOC105377148 Neighboring gene SUCLG2 antisense RNA 1 (head to head) Neighboring gene FAM19A1 intron homotypic cluster of transcription factor binding sites enhancer Neighboring gene COP9 signalosome subunit 8 pseudogene 2 Neighboring gene uncharacterized LOC107986019 Neighboring gene uncharacterized LOC105377146 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 8 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein FAM19A1
    Names
    chemokine-like protein TAFA-1
    family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252216.1NP_001239145.1  protein FAM19A1 precursor

      See identical proteins and their annotated locations for NP_001239145.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC139766, AY325114, BC025746
      Consensus CDS
      CCDS54606.1
      UniProtKB/Swiss-Prot
      Q7Z5A9
      Conserved Domains (1) summary
      pfam12020
      Location:41128
      TAFA; TAFA family
    2. NM_213609.3NP_998774.2  protein FAM19A1 precursor

      See identical proteins and their annotated locations for NP_998774.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK290446, BC025746, DA484048, DA485098
      Consensus CDS
      CCDS54606.1
      UniProtKB/Swiss-Prot
      Q7Z5A9
      Related
      ENSP00000418575.1, OTTHUMP00000213370, ENST00000478136.5, OTTHUMT00000352004
      Conserved Domains (1) summary
      pfam12020
      Location:41128
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      67991592..68546056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006390.1XP_016861879.1  protein FAM19A1 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:40127
      TAFA; TAFA family
    2. XM_017006388.1XP_016861877.1  protein FAM19A1 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:40127
      TAFA; TAFA family
    3. XM_017006387.2XP_016861876.1  protein FAM19A1 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z5A9
      Conserved Domains (1) summary
      pfam12020
      Location:41128
      TAFA; TAFA family
    4. XM_017006386.1XP_016861875.1  protein FAM19A1 isoform X1

      UniProtKB/Swiss-Prot
      Q7Z5A9
      Related
      ENSP00000417496.1, OTTHUMP00000213371, ENST00000496687.1, OTTHUMT00000352005
      Conserved Domains (1) summary
      pfam12020
      Location:41128
      TAFA; TAFA family
    5. XM_017006389.1XP_016861878.1  protein FAM19A1 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:40127
      TAFA; TAFA family
    Support Center