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    CR2 complement C3d receptor 2 [ Bos taurus (cattle) ]

    Gene ID: 407126, updated on 27-Aug-2018

    Summary

    Official Symbol
    CR2provided by VGNC
    Official Full Name
    complement C3d receptor 2provided by VGNC
    Primary source
    VGNC:VGNC:27684
    See related
    BGD:BT27305; Ensembl:ENSBTAG00000038496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    cd21
    Orthologs

    Genomic context

    See CR2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 16 NC_037343.1 (5397365..5446688)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 16 AC_000173.1 (5253453..5302733)

    Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene CD55 molecule (Cromer blood group) Neighboring gene up-regulated during skeletal muscle growth protein 5 pseudogene Neighboring gene complement receptor type 1 Neighboring gene chromobox protein homolog 1 pseudogene

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...

    General gene information

    Homology

    General protein information

    Preferred Names
    complement receptor type 2
    Names
    complement component (3d/Epstein Barr virus) receptor 2
    complement component receptor 2
    complement receptor 1 long isoform

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198991.1NP_001185920.1  complement receptor type 2 precursor

      See identical proteins and their annotated locations for NP_001185920.1

      Status: PROVISIONAL

      Source sequence(s)
      HM461977
      UniProtKB/TrEMBL
      E3UM64
      Related
      ENSBTAP00000054595.1, ENSBTAT00000063039.1
      Conserved Domains (3) summary
      cd00033
      Location:532589
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02927
      Location:10274
      PHA02927; secreted complement-binding protein; Provisional
      pfam00084
      Location:83140
      Sushi; Sushi repeat (SCR repeat)

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037343.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      5397365..5446688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024976066.1XP_024831834.1  complement receptor type 2 isoform X1

      Conserved Domains (1) summary
      cl27761
      Location:10274
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    2. XM_024976068.1XP_024831836.1  complement receptor type 2 isoform X3

      Conserved Domains (1) summary
      cl27761
      Location:153407
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    3. XM_024976069.1XP_024831837.1  complement receptor type 2 isoform X4

      Conserved Domains (1) summary
      cl27761
      Location:153407
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    4. XM_024976067.1XP_024831835.1  complement receptor type 2 isoform X2

      Conserved Domains (1) summary
      cl27761
      Location:2174
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
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