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    EGR1 early growth response 1 [ Bos taurus (cattle) ]

    Gene ID: 407125, updated on 2-Oct-2018

    Summary

    Official Symbol
    EGR1provided by VGNC
    Official Full Name
    early growth response 1provided by VGNC
    Primary source
    VGNC:VGNC:52766
    See related
    BGD:BT24351; Ensembl:ENSBTAG00000010069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs

    Genomic context

    See EGR1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current ARS-UCD1.2 (GCF_002263795.1) 7 NC_037334.1 (49826725..49829568)
    105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 7 AC_000164.1 (51438972..51441815)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 2 Neighboring gene uncharacterized LOC101904825 Neighboring gene eukaryotic translation termination factor 1 Neighboring gene POU domain, class 5, transcription factor 1 pseudogene Neighboring gene small nucleolar RNA SNORD63 Neighboring gene heat shock protein family A (Hsp70) member 9

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • Apelin signaling pathway, organism-specific biosystem (from KEGG)
      Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
    • NRF2 pathway, organism-specific biosystem (from WikiPathways)
      NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
    • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
    • Ovarian Infertility Genes, organism-specific biosystem (from WikiPathways)
      Ovarian Infertility Genes, organism-specific biosystemOvarian bottleneck genes associated with infertility. A valuable approach to the study of infertility is the comparison of mutations of individual human and mouse genes associated with infertility ph...
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystem (from WikiPathways)
      Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...

    General gene information

    Homology

    Clone Names

    • MGC139820

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    double-stranded methylated DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hemi-methylated DNA-binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    promoter-specific chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cellular response to heparin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to interleukin-8 ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to mycophenolic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    estrous cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glomerular mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of chemokine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glomerular metanephric mesangial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of hormone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-1 beta biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of progesterone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to ischemia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    early growth response protein 1
    Names
    EGR-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045875.1NP_001039340.1  early growth response protein 1

      See identical proteins and their annotated locations for NP_001039340.1

      Status: PROVISIONAL

      Source sequence(s)
      AY924307
      UniProtKB/Swiss-Prot
      Q29W20
      Related
      ENSBTAP00000013284.5, ENSBTAT00000013284.5
      Conserved Domains (6) summary
      sd00017
      Location:339361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:337361
      zf-C2H2; Zinc finger, C2H2 type
      pfam05687
      Location:436502
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
      pfam11914
      Location:444527
      DUF3432; Domain of unknown function (DUF3432)
      pfam11928
      Location:135208
      DUF3446; Domain of unknown function (DUF3446)
      pfam13465
      Location:380405
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD1.2 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD1.2 Primary Assembly

      Range
      49826725..49829568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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