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    msh2 mutS homolog 2 (E. coli) [ Danio rerio (zebrafish) ]

    Gene ID: 406845, updated on 2-Oct-2018

    Summary

    Official Symbol
    msh2provided by ZNC
    Official Full Name
    mutS homolog 2 (E. coli)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2932
    See related
    Ensembl:ENSDARG00000018022 Vega:OTTDARG00000027380
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    zgc:55333; wu:fc06b02; wu:fc13e09
    Orthologs

    Genomic context

    See msh2 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (24906108..24928497, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (24784889..24807278, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene forkhead box N2b Neighboring gene F-box protein 11b Neighboring gene calmodulin 2b, (phosphorylase kinase, delta) Neighboring gene suppressor of cytokine signaling 5a

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-dependent ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to four-way junction DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to guanine/thymine mispair binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    guanine/thymine mispair binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    guanine/thymine mispair binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to single thymine insertion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intra-S DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maintenance of DNA repeat elements IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maintenance of DNA repeat elements IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair IEA
    Inferred from Electronic Annotation
    more info
     
    mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to UV-B IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    MutSalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MutSbeta complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    DNA mismatch repair protein Msh2
    Names
    mismatch repair protein Msh2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213524.1NP_998689.1  DNA mismatch repair protein Msh2

      See identical proteins and their annotated locations for NP_998689.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044370
      UniProtKB/TrEMBL
      Q803R6
      Related
      ENSDARP00000027768.6, OTTDARP00000029502, ENSDART00000002465.7, OTTDART00000036796
      Conserved Domains (6) summary
      cd03285
      Location:633852
      ABC_MSH2_euk; ATP-binding cassette domain of eukaryotic MutS2 homolog
      COG0249
      Location:23911
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam01624
      Location:17129
      MutS_I; MutS domain I
      pfam05188
      Location:158283
      MutS_II; MutS domain II
      pfam05190
      Location:473569
      MutS_IV; MutS family domain IV
      pfam05192
      Location:305423
      MutS_III; MutS domain III

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      24906108..24928497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394844.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      243375..265764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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