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    sqstm1 sequestosome 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406452, updated on 21-Oct-2018

    Summary

    Official Symbol
    sqstm1provided by ZNC
    Official Full Name
    sequestosome 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2204
    See related
    Ensembl:ENSDARG00000075014 Vega:OTTDARG00000027873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    sb:cb621; zgc:85784
    Orthologs

    Genomic context

    See sqstm1 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16765992..16771405)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (16460339..16465752)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene calnexin Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b Neighboring gene MRN complex interacting protein

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    K63-linked polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    aggrephagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    aggresome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amphisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001312913.1NP_001299842.1  sequestosome-1

      Status: VALIDATED

      Source sequence(s)
      CU075768, DR724012, EH505876, EH510853
      UniProtKB/TrEMBL
      F1Q5Z8
      Related
      ENSDARP00000117113.1, OTTDARP00000030230, ENSDART00000140061.3, OTTDART00000037711
      Conserved Domains (3) summary
      cd06402
      Location:388
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:148190
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl21463
      Location:390448
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      16765992..16771405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_213173.1: Suppressed sequence

      Description
      NM_213173.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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