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    LTA4H leukotriene A4 hydrolase [ Homo sapiens (human) ]

    Gene ID: 4048, updated on 8-Jul-2018
    Official Symbol
    LTA4Hprovided by HGNC
    Official Full Name
    leukotriene A4 hydrolaseprovided by HGNC
    Primary source
    HGNC:HGNC:6710
    See related
    Ensembl:ENSG00000111144 MIM:151570; Vega:OTTHUMG00000170355
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in lung (RPKM 63.8), bone marrow (RPKM 53.7) and 25 other tissues See more
    Orthologs
    See LTA4H in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (96000753..96043520, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96394531..96437298, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 38 Neighboring gene amidohydrolase domain containing 1 Neighboring gene uncharacterized LOC102723340 Neighboring gene histidine ammonia-lyase Neighboring gene transfer RNA-Asp (GTC) 2-8 Neighboring gene YPEL5 pseudogene 3 Neighboring gene uncharacterized LOC105369923 Neighboring gene RNA, 7SL, cytoplasmic 88, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
    NHGRI GWA Catalog
    • Arachidonic acid metabolism, organism-specific biosystem (from KEGG)
      Arachidonic acid metabolism, organism-specific biosystem
      Arachidonic acid metabolism
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Arachidonic acid metabolism, conserved biosystem (from KEGG)
      Arachidonic acid metabolism, conserved biosystem
      Arachidonic acid metabolism
    • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
      Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
      Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
    • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
      leukotriene biosynthesis, organism-specific biosystemLeukotrienes are made by cells of the immune system, mainly the mediators of inflammation like polymorphonuclear leukocytes, macrophages and mast cells. Cellular activation during inflammation leads ...
    • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
      leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ17564

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    epoxide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epoxide hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epoxide hydrolase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    leukotriene-A4 hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukotriene-A4 hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene-A4 hydrolase activity TAS
    Traceable Author Statement
    more info
     
    metalloaminopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukotriene biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    long-chain fatty acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    peptide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    tertiary granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    leukotriene A-4 hydrolase
    Names
    LTA-4 hydrolase
    testicular secretory protein Li 27
    NP_000886.1
    NP_001243572.1
    NP_001243573.1
    XP_005268928.1
    XP_011536651.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000895.2NP_000886.1  leukotriene A-4 hydrolase isoform 1

      See identical proteins and their annotated locations for NP_000886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      DB019628, J03459, R41544
      Consensus CDS
      CCDS9059.1
      UniProtKB/Swiss-Prot
      P09960
      UniProtKB/TrEMBL
      A0A140VK27
      Related
      ENSP00000228740.2, OTTHUMP00000243570, ENST00000228740.6, OTTHUMT00000408655
      Conserved Domains (1) summary
      TIGR02411
      Location:6608
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
    2. NM_001256643.1NP_001243572.1  leukotriene A-4 hydrolase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC032528, BX647158, DC358373, R41544
      Consensus CDS
      CCDS58267.1
      UniProtKB/Swiss-Prot
      P09960
      Related
      ENSP00000449958.1, OTTHUMP00000243571, ENST00000552789.5, OTTHUMT00000408657
      Conserved Domains (3) summary
      cd09599
      Location:30426
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:30584
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:444583
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    3. NM_001256644.1NP_001243573.1  leukotriene A-4 hydrolase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon and lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK298017, AK308184, R41544
      Consensus CDS
      CCDS58266.1
      UniProtKB/Swiss-Prot
      P09960
      Related
      ENSP00000395051.2, OTTHUMP00000243572, ENST00000413268.6, OTTHUMT00000408660
      Conserved Domains (2) summary
      cd09599
      Location:30426
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      pfam09127
      Location:444492
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RNA

    1. NR_132659.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007298, AI582379, AK293630, AK298017, DB019628, R41544

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      96000753..96043520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268871.2XP_005268928.1  leukotriene A-4 hydrolase isoform X1

      See identical proteins and their annotated locations for XP_005268928.1

      UniProtKB/Swiss-Prot
      P09960
      Conserved Domains (1) summary
      cl28130
      Location:6514
      Peptidase_M1; Peptidase family M1
    2. XM_011538349.3XP_011536651.1  leukotriene A-4 hydrolase isoform X2

      Conserved Domains (2) summary
      cd09599
      Location:6450
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      pfam01433
      Location:21387
      Peptidase_M1; Peptidase family M1

    RNA

    1. XR_002957326.1 RNA Sequence

    2. XR_001748703.2 RNA Sequence

      Related
      ENST00000548852.5
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