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    DLD dihydrolipoamide dehydrogenase [ Canis lupus familiaris (dog) ]

    Gene ID: 403978, updated on 28-May-2018

    Summary

    Official Symbol
    DLDprovided by VGNC
    Official Full Name
    dihydrolipoamide dehydrogenaseprovided by VGNC
    Primary source
    VGNC:VGNC:39976
    See related
    Ensembl:ENSCAFG00000003837
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs

    Genomic context

    See DLD in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    105 current CanFam3.1 (GCF_000002285.3) 18 NC_006600.3 (12703340..12734408, complement)

    Chromosome 18 - NC_006600.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090889 Neighboring gene laminin subunit beta 1 Neighboring gene uncharacterized LOC106559946 Neighboring gene solute carrier family 26 member 3

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_006600.3 Chromosome 18 Reference CanFam3.1 Primary Assembly

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    dihydrolipoyl dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    histone succinylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxoglutarate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dihydrolipoyl dehydrogenase, mitochondrial
    Names
    dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)
    dihydrolipoamide: NAD+ oxidoreductase
    NP_001003294.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003294.1NP_001003294.1  dihydrolipoyl dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001003294.1

      Status: PROVISIONAL

      Source sequence(s)
      U19872
      UniProtKB/Swiss-Prot
      P49819
      Related
      ENSCAFP00000005721.2, ENSCAFT00000006177.2
      Conserved Domains (4) summary
      PRK06467
      Location:40501
      PRK06467; dihydrolipoamide dehydrogenase; Reviewed
      pfam00070
      Location:215288
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam02852
      Location:390496
      Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
      cl21454
      Location:45222
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 105 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CanFam3.1 Primary Assembly

    Genomic

    1. NC_006600.3 Reference CanFam3.1 Primary Assembly

      Range
      12703340..12734408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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